Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach
Abstract This study developed and validated an artificial intelligence (AI)-based computational tool for standardizing glucose and urea measurements across different clinical laboratory systems (Biolabo and BioScien) using Biomagreb as the reference standard. Through empirical analysis of parallel-t...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-025-01351-1 |
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| author | Abdulwahab AL-Deib Eshraq Alsherif Husameddin Abuzgaia Amel Rabti Ruwaida Rtemi Salem Elfard Sheren Njaim |
| author_facet | Abdulwahab AL-Deib Eshraq Alsherif Husameddin Abuzgaia Amel Rabti Ruwaida Rtemi Salem Elfard Sheren Njaim |
| author_sort | Abdulwahab AL-Deib |
| collection | DOAJ |
| description | Abstract This study developed and validated an artificial intelligence (AI)-based computational tool for standardizing glucose and urea measurements across different clinical laboratory systems (Biolabo and BioScien) using Biomagreb as the reference standard. Through empirical analysis of parallel-tested blood samples, four linear regression models were established, demonstrating excellent predictive accuracy (R2 > 0.99, mean absolute error < 1.2%). The glucose conversion models yielded precise transformations (Biolabo: Y = 1.01X−0.03357; BioScien: Y = 1.141X−13.71), while urea models showed robust consistency (Biolabo: Y = 0.9312X + 1.549; BioScien: Y = 0.7073X + 5.252). Validation confirmed near-perfect agreement with manual calculations, with minor discrepancies (≤ 0.5%) attributable only to rounding effects. The AI-driven software implementation enhanced clinical utility by automating conversions, displaying normal ranges, and eliminating human calculation errors. Despite high accuracy, limitations include unit restriction (mg/dL only), single-value processing, and lack of batch export functionality. The study highlights AI’s transformative role in laboratory standardization, particularly through machine learning (ML) techniques like linear regression and random forests. Challenges like data quality, understanding the model, and following regulations were tackled using explainable AI (XAI) and strict validation methods. Future improvements should expand analyte coverage, incorporate mmol/L conversion, and enable batch processing. These findings support AI’s potential to enhance diagnostic reliability and inter-laboratory comparability in clinical settings. |
| format | Article |
| id | doaj-art-b8982460dd9d44e2b165b2597ca9b085 |
| institution | Kabale University |
| issn | 2522-8307 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj-art-b8982460dd9d44e2b165b2597ca9b0852025-08-24T11:06:33ZengSpringerOpenBulletin of the National Research Centre2522-83072025-08-014911710.1186/s42269-025-01351-1Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approachAbdulwahab AL-Deib0Eshraq Alsherif1Husameddin Abuzgaia2Amel Rabti3Ruwaida Rtemi4Salem Elfard5Sheren Njaim6Department of Medical Laboratory, University of Tripoli AlahliaDepartment of Medical Laboratory, University of Tripoli AlahliaDepartment of Computer Science and Information Technology, University of Tripoli AlahliaDepartment of Medical Laboratory, University of Tripoli AlahliaDepartment of Computer Science and Information Technology, University of Tripoli AlahliaDepartment of Software Engineering, Faculty of Information Technology, University of ZawiaUniversity of Tripoli AlahliaAbstract This study developed and validated an artificial intelligence (AI)-based computational tool for standardizing glucose and urea measurements across different clinical laboratory systems (Biolabo and BioScien) using Biomagreb as the reference standard. Through empirical analysis of parallel-tested blood samples, four linear regression models were established, demonstrating excellent predictive accuracy (R2 > 0.99, mean absolute error < 1.2%). The glucose conversion models yielded precise transformations (Biolabo: Y = 1.01X−0.03357; BioScien: Y = 1.141X−13.71), while urea models showed robust consistency (Biolabo: Y = 0.9312X + 1.549; BioScien: Y = 0.7073X + 5.252). Validation confirmed near-perfect agreement with manual calculations, with minor discrepancies (≤ 0.5%) attributable only to rounding effects. The AI-driven software implementation enhanced clinical utility by automating conversions, displaying normal ranges, and eliminating human calculation errors. Despite high accuracy, limitations include unit restriction (mg/dL only), single-value processing, and lack of batch export functionality. The study highlights AI’s transformative role in laboratory standardization, particularly through machine learning (ML) techniques like linear regression and random forests. Challenges like data quality, understanding the model, and following regulations were tackled using explainable AI (XAI) and strict validation methods. Future improvements should expand analyte coverage, incorporate mmol/L conversion, and enable batch processing. These findings support AI’s potential to enhance diagnostic reliability and inter-laboratory comparability in clinical settings.https://doi.org/10.1186/s42269-025-01351-1Artificial intelligenceLinear regressionDiagnostic accuracyMedical laboratory departmentUniversity of Tripoli Alahlia |
| spellingShingle | Abdulwahab AL-Deib Eshraq Alsherif Husameddin Abuzgaia Amel Rabti Ruwaida Rtemi Salem Elfard Sheren Njaim Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach Bulletin of the National Research Centre Artificial intelligence Linear regression Diagnostic accuracy Medical laboratory department University of Tripoli Alahlia |
| title | Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach |
| title_full | Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach |
| title_fullStr | Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach |
| title_full_unstemmed | Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach |
| title_short | Predicting laboratory solution kit accuracy using artificial intelligence: a data-driven approach |
| title_sort | predicting laboratory solution kit accuracy using artificial intelligence a data driven approach |
| topic | Artificial intelligence Linear regression Diagnostic accuracy Medical laboratory department University of Tripoli Alahlia |
| url | https://doi.org/10.1186/s42269-025-01351-1 |
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