Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study
Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four...
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MDPI AG
2025-02-01
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| author | Siting Li Shiyi Yang Xiaoning Sun Tianxiang Ma Yuehong Zheng Xiao Liu |
| author_facet | Siting Li Shiyi Yang Xiaoning Sun Tianxiang Ma Yuehong Zheng Xiao Liu |
| author_sort | Siting Li |
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| description | Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four AAA patients with ILT were enrolled. Patient-specific models of the aorta and branch arteries were constructed followed by CFD simulations. NO concentration was modeled based on endothelial shear stress response and its transport within the arterial lumen and wall. Hemodynamic parameters, including wall shear stress (WSS) and its derivatives, were analyzed alongside NO distribution. ILT accumulation was primarily located in the infrarenal abdominal aorta. Regions of decreased NO concentration correlated with ILT accumulated areas, whereas regions with decreased TAWSS and increased OSI were less consistent with ILT accumulation. A negative correlation was observed between the thrombus area and NO concentration, with <i>p</i> values of less than 0.001 for four patients. The time-average area NO concentration values of lumen area with ILT were lower than those of non-ILT sections. Spatially, NO was unevenly distributed, with thicker thrombus in regions of lower NO concentration. NO distribution could serve as a better potential personalized marker for thrombosis prediction in AAA compared to WSS-derived parameters. |
| format | Article |
| id | doaj-art-b8954dfd6e4e4e27b347140b7be06527 |
| institution | DOAJ |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-b8954dfd6e4e4e27b347140b7be065272025-08-20T02:44:36ZengMDPI AGBioengineering2306-53542025-02-0112219110.3390/bioengineering12020191Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational StudySiting Li0Shiyi Yang1Xiaoning Sun2Tianxiang Ma3Yuehong Zheng4Xiao Liu5Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, ChinaIntraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specific computational fluid dynamics (CFD) models. Four AAA patients with ILT were enrolled. Patient-specific models of the aorta and branch arteries were constructed followed by CFD simulations. NO concentration was modeled based on endothelial shear stress response and its transport within the arterial lumen and wall. Hemodynamic parameters, including wall shear stress (WSS) and its derivatives, were analyzed alongside NO distribution. ILT accumulation was primarily located in the infrarenal abdominal aorta. Regions of decreased NO concentration correlated with ILT accumulated areas, whereas regions with decreased TAWSS and increased OSI were less consistent with ILT accumulation. A negative correlation was observed between the thrombus area and NO concentration, with <i>p</i> values of less than 0.001 for four patients. The time-average area NO concentration values of lumen area with ILT were lower than those of non-ILT sections. Spatially, NO was unevenly distributed, with thicker thrombus in regions of lower NO concentration. NO distribution could serve as a better potential personalized marker for thrombosis prediction in AAA compared to WSS-derived parameters.https://www.mdpi.com/2306-5354/12/2/191abdominal aortic aneurysmintraluminal thrombusnitric oxidecomputational fluid dynamics |
| spellingShingle | Siting Li Shiyi Yang Xiaoning Sun Tianxiang Ma Yuehong Zheng Xiao Liu Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study Bioengineering abdominal aortic aneurysm intraluminal thrombus nitric oxide computational fluid dynamics |
| title | Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study |
| title_full | Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study |
| title_fullStr | Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study |
| title_full_unstemmed | Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study |
| title_short | Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study |
| title_sort | nitric oxide distribution correlates with intraluminal thrombus in abdominal aortic aneurysm a computational study |
| topic | abdominal aortic aneurysm intraluminal thrombus nitric oxide computational fluid dynamics |
| url | https://www.mdpi.com/2306-5354/12/2/191 |
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