The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method
Double divisor-ratio spectra derivative method based on the spectrophotometric data was developed for the simultaneous analysis of a ternary mixture containing paracetamol, aspirin, and caffeine, without prior separation. This method is based on the use of the derivative of the ratio spectrum obtain...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2013/405210 |
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| author | Reza Hajian Ahmad Soltaninezhad |
| author_facet | Reza Hajian Ahmad Soltaninezhad |
| author_sort | Reza Hajian |
| collection | DOAJ |
| description | Double divisor-ratio spectra derivative method based on the spectrophotometric data was developed for the simultaneous analysis of a ternary mixture containing paracetamol, aspirin, and caffeine, without prior separation. This method is based on the use of the derivative of the ratio spectrum obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of a mixture of two of the three compounds in the title mixture. The concentrations of three compounds in their mixture are determined by using their respective calibration graphs which are obtained by measuring the amplitude at either the maximum or minimum wavelengths selected. The selected wavelengths for determination of aspirin, caffeine, and paracetamol are 241.5, 256, and 258.5 nm, respectively. All of the solutions adjusted to pH 11 before recording the spectra in the range of 220 to 320 nm. Also, the mathematical explanation of the procedure is illustrated. The method was applied for the assay of Excedrin containing paracetamol, aspirin, and caffeine. |
| format | Article |
| id | doaj-art-b892f12d3e2f4258ad47b69eae01bffe |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-b892f12d3e2f4258ad47b69eae01bffe2025-02-03T05:57:49ZengWileyJournal of Spectroscopy2314-49202314-49392013-01-01201310.1155/2013/405210405210The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative MethodReza Hajian0Ahmad Soltaninezhad1Young Researchers Club, Gachsaran Branch, Islamic Azad University, 7581863876 Gachsaran, IranChemistry Department, Gachsaran Branch, Islamic Azad University, 7581863876 Gachsaran, IranDouble divisor-ratio spectra derivative method based on the spectrophotometric data was developed for the simultaneous analysis of a ternary mixture containing paracetamol, aspirin, and caffeine, without prior separation. This method is based on the use of the derivative of the ratio spectrum obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of a mixture of two of the three compounds in the title mixture. The concentrations of three compounds in their mixture are determined by using their respective calibration graphs which are obtained by measuring the amplitude at either the maximum or minimum wavelengths selected. The selected wavelengths for determination of aspirin, caffeine, and paracetamol are 241.5, 256, and 258.5 nm, respectively. All of the solutions adjusted to pH 11 before recording the spectra in the range of 220 to 320 nm. Also, the mathematical explanation of the procedure is illustrated. The method was applied for the assay of Excedrin containing paracetamol, aspirin, and caffeine.http://dx.doi.org/10.1155/2013/405210 |
| spellingShingle | Reza Hajian Ahmad Soltaninezhad The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method Journal of Spectroscopy |
| title | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method |
| title_full | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method |
| title_fullStr | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method |
| title_full_unstemmed | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method |
| title_short | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Paracetamol, Aspirin, and Caffeine by the Double Divisor-Ratio Spectra Derivative Method |
| title_sort | spectrophotometric multicomponent analysis of a ternary mixture of paracetamol aspirin and caffeine by the double divisor ratio spectra derivative method |
| url | http://dx.doi.org/10.1155/2013/405210 |
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