The oral microbiome and oral and upper gastrointestinal diseases
Background Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2024.2355823 |
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| _version_ | 1850067796928495616 |
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| author | Sifan Liu Shidong Wang Nan Zhang Peng Li |
| author_facet | Sifan Liu Shidong Wang Nan Zhang Peng Li |
| author_sort | Sifan Liu |
| collection | DOAJ |
| description | Background Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment.Methods To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as “oral microbiome,” “oral flora, ” “gastrointestinal disease, ” without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review.Results In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases.Conclusions Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions. |
| format | Article |
| id | doaj-art-b891a6ef1dde4add971c0c819d125649 |
| institution | DOAJ |
| issn | 2000-2297 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-b891a6ef1dde4add971c0c819d1256492025-08-20T02:48:12ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972024-12-0116110.1080/20002297.2024.2355823The oral microbiome and oral and upper gastrointestinal diseasesSifan Liu0Shidong Wang1Nan Zhang2Peng Li3Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory for Digestive Health; National Clinical Research Center for Digestive Diseases, Beijing, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory for Digestive Health; National Clinical Research Center for Digestive Diseases, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; State Key Laboratory for Digestive Health; National Clinical Research Center for Digestive Diseases, Beijing, ChinaBackground Microbiomes are essential components of the human body, and their populations are substantial. Under normal circumstances, microbiomes coexist harmoniously with the human body, but disturbances in this equilibrium can lead to various diseases. The oral microbiome is involved in the occurrence and development of many oral and gastrointestinal diseases. This review focuses on the relationship between oral microbiomes and oral and upper gastrointestinal diseases, and therapeutic strategies aiming to provide valuable insights for clinical prevention and treatment.Methods To identify relevant studies, we conducted searches in PubMed, Google Scholar, and Web of Science using keywords such as “oral microbiome,” “oral flora, ” “gastrointestinal disease, ” without any date restrictions. Subsequently, the retrieved publications were subject to a narrative review.Results In this review, we found that oral microbiomes are closely related to oral and gastrointestinal diseases such as periodontitis, dental caries, reflux esophagitis, gastritis, and upper gastrointestinal tumors (mainly the malignant ones). Oral samples like saliva and buccal mucosa are not only easy to collect, but also display superior sample stability compared to gastrointestinal tissues. Consequently, analysis of the oral microbiome could potentially serve as an efficient preliminary screening method for high-risk groups before undergoing endoscopic examination. Besides, treatments based on the oral microbiomes could aid early diagnosis and treatment of these diseases.Conclusions Oral microbiomes are essential to oral and gastrointestinal diseases. Therapies centered on the oral microbiomes could facilitate the early detection and management of these conditions.https://www.tandfonline.com/doi/10.1080/20002297.2024.2355823Oral microbiomeupper gastrointestinal diseasemicrobiotadigestive diseasecancer |
| spellingShingle | Sifan Liu Shidong Wang Nan Zhang Peng Li The oral microbiome and oral and upper gastrointestinal diseases Journal of Oral Microbiology Oral microbiome upper gastrointestinal disease microbiota digestive disease cancer |
| title | The oral microbiome and oral and upper gastrointestinal diseases |
| title_full | The oral microbiome and oral and upper gastrointestinal diseases |
| title_fullStr | The oral microbiome and oral and upper gastrointestinal diseases |
| title_full_unstemmed | The oral microbiome and oral and upper gastrointestinal diseases |
| title_short | The oral microbiome and oral and upper gastrointestinal diseases |
| title_sort | oral microbiome and oral and upper gastrointestinal diseases |
| topic | Oral microbiome upper gastrointestinal disease microbiota digestive disease cancer |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2024.2355823 |
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