Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort
Objective To evaluate the sensitivity to change in structural imaging outcomes over 10 years of follow-up in patients with axial spondyloarthritis (axSpA).Methods Patients with axSpA from the Devenir des Spondyloarthropathies Indifferénciées Récentes cohort were included. Radiographs and MRIs of the...
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BMJ Publishing Group
2024-09-01
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| author | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Alexandre Sepriano Anne Tournadre |
| author_facet | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Alexandre Sepriano Anne Tournadre |
| author_sort | Sofia Ramiro |
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| description | Objective To evaluate the sensitivity to change in structural imaging outcomes over 10 years of follow-up in patients with axial spondyloarthritis (axSpA).Methods Patients with axSpA from the Devenir des Spondyloarthropathies Indifferénciées Récentes cohort were included. Radiographs and MRIs of the sacroiliac joints (SIJ) and spine were obtained at baseline and at 1, 2, 5 and 10 years. The yearly rate of change of each structural outcome was analysed using generalised estimating equation models, including all patients with ≥1 score from ≥1 reader from ≥1 reading wave, using the time (years) as an explanatory variable and adjusting for reader and wave. All outcomes were standardised, and the relative standardised rate of change was calculated (ie, the standardised rate of an outcome divided by the rate of a reference outcome).Results A total of 659 patients (46% males and mean age 33.6 years) were included. The most sensitive outcome to change in the SIJ (both MRI and radiographs) was the presence of ≥3 fatty lesions at a specific timepoint, with a relative standardised rate of change per year of 5.28 using the modified New York criteria as reference.Similarly, the most sensitive to change (in both MRI and radiographs) outcome in the spine was the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS; relative standardised yearly change 1.76) using ≥1 syndesmophyte as reference.Conclusion MRI structural outcomes in the SIJ (ie, fatty lesions) are more sensitive to change than radiographic outcomes. Conversely, the mSASSS remains the most sensitive method, even when compared with MRI of the spine. |
| format | Article |
| id | doaj-art-b8912d8cd4c94d8a8c316e110c61b69d |
| institution | DOAJ |
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| language | English |
| publishDate | 2024-09-01 |
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| spelling | doaj-art-b8912d8cd4c94d8a8c316e110c61b69d2025-08-20T03:09:59ZengBMJ Publishing GroupRMD Open2056-59332024-09-0110310.1136/rmdopen-2024-004400Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohortSofia Ramiro0Maxime Dougados1Anna Molto2Clementina López-Medina3Alexandre Sepriano4Anne Tournadre5Department of Rheumatology, Zuyderland Medical Centre Heerlen, Heerlen, The Netherlands6 Rhumatologie B, Hopital Cochin, 27 rue du Fbg Saint-Jacques, Paris, FranceCRESS, INSERM U1153, Paris-Cité University, Paris, FranceMaimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain1 Rheumatology, Leiden University Medical Center, Leiden, The Netherlands1 Department of Rheumatology, CHU Clermont-Ferrand, Clermont-Ferrand, FranceObjective To evaluate the sensitivity to change in structural imaging outcomes over 10 years of follow-up in patients with axial spondyloarthritis (axSpA).Methods Patients with axSpA from the Devenir des Spondyloarthropathies Indifferénciées Récentes cohort were included. Radiographs and MRIs of the sacroiliac joints (SIJ) and spine were obtained at baseline and at 1, 2, 5 and 10 years. The yearly rate of change of each structural outcome was analysed using generalised estimating equation models, including all patients with ≥1 score from ≥1 reader from ≥1 reading wave, using the time (years) as an explanatory variable and adjusting for reader and wave. All outcomes were standardised, and the relative standardised rate of change was calculated (ie, the standardised rate of an outcome divided by the rate of a reference outcome).Results A total of 659 patients (46% males and mean age 33.6 years) were included. The most sensitive outcome to change in the SIJ (both MRI and radiographs) was the presence of ≥3 fatty lesions at a specific timepoint, with a relative standardised rate of change per year of 5.28 using the modified New York criteria as reference.Similarly, the most sensitive to change (in both MRI and radiographs) outcome in the spine was the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS; relative standardised yearly change 1.76) using ≥1 syndesmophyte as reference.Conclusion MRI structural outcomes in the SIJ (ie, fatty lesions) are more sensitive to change than radiographic outcomes. Conversely, the mSASSS remains the most sensitive method, even when compared with MRI of the spine.https://rmdopen.bmj.com/content/10/3/e004400.full |
| spellingShingle | Sofia Ramiro Maxime Dougados Anna Molto Clementina López-Medina Alexandre Sepriano Anne Tournadre Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort RMD Open |
| title | Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort |
| title_full | Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort |
| title_fullStr | Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort |
| title_full_unstemmed | Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort |
| title_short | Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort |
| title_sort | sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up data from the desir cohort |
| url | https://rmdopen.bmj.com/content/10/3/e004400.full |
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