Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report
Atypical hemolytic uremic syndrome (aHUS), a rare disease caused by complement abnormalities, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In this paper, we report a patient with severe renal insufficiency with rapidly progressive decline in binoc...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2024-12-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0471 |
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| author | MEI Qimin DAI Jiayuan LIU Yecheng SHEN Min ZHU Huadong |
| author_facet | MEI Qimin DAI Jiayuan LIU Yecheng SHEN Min ZHU Huadong |
| author_sort | MEI Qimin |
| collection | DOAJ |
| description | Atypical hemolytic uremic syndrome (aHUS), a rare disease caused by complement abnormalities, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In this paper, we report a patient with severe renal insufficiency with rapidly progressive decline in binocular visual acuity, who developed eosinophilia during the course of the disease, and was diagnosed with aHUS after excluding other diseases. After glucocorticoid treatment, eosinophils decreased to normal, and after treatment with plasmapheresis combined with eculizumab, renal function tended to be stable, platelets returned to normal, but visual acuity did not improve significantly. This article reviews the diagnosis and treatment process of this patient and incorporates the review of literature, in the hope of providing reference for clinicians. |
| format | Article |
| id | doaj-art-b890d3fbfbcd4303907096a5f777730e |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-b890d3fbfbcd4303907096a5f777730e2025-02-08T07:47:34ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812024-12-0116125626210.12290/xhyxzz.2024-0471Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case ReportMEI QiminDAI JiayuanLIU YechengSHEN MinZHU HuadongAtypical hemolytic uremic syndrome (aHUS), a rare disease caused by complement abnormalities, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In this paper, we report a patient with severe renal insufficiency with rapidly progressive decline in binocular visual acuity, who developed eosinophilia during the course of the disease, and was diagnosed with aHUS after excluding other diseases. After glucocorticoid treatment, eosinophils decreased to normal, and after treatment with plasmapheresis combined with eculizumab, renal function tended to be stable, platelets returned to normal, but visual acuity did not improve significantly. This article reviews the diagnosis and treatment process of this patient and incorporates the review of literature, in the hope of providing reference for clinicians.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0471atypical hemolytic uremic syndromeeosinophiliarenal insufficiencyvision loss |
| spellingShingle | MEI Qimin DAI Jiayuan LIU Yecheng SHEN Min ZHU Huadong Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report Xiehe Yixue Zazhi atypical hemolytic uremic syndrome eosinophilia renal insufficiency vision loss |
| title | Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report |
| title_full | Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report |
| title_fullStr | Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report |
| title_full_unstemmed | Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report |
| title_short | Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report |
| title_sort | atypical hemolytic uremic syndrome with eosinophilia and purtscher like retinopathy a case report |
| topic | atypical hemolytic uremic syndrome eosinophilia renal insufficiency vision loss |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0471 |
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