Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials
Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women. Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/741639 |
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| _version_ | 1850176936282685440 |
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| author | George A. Kelley Kristi S. Kelley Wendy M. Kohrt |
| author_facet | George A. Kelley Kristi S. Kelley Wendy M. Kohrt |
| author_sort | George A. Kelley |
| collection | DOAJ |
| description | Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women. Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and pooled using random-effects models, Z score alpha values, 95% confidence intervals (CIs), and number needed to treat (NNT). Heterogeneity was examined using Q and I2. Moderator and predictor analyses using mixed-effects ANOVA and simple metaregression were conducted. Statistical significance was set at P≤0.05. Results. Statistically significant improvements were found for both FN (7g's, 466 participants, g=0.342, 95% CI=0.132, 0.553, P=0.001, Q=10.8, P=0.22, I2=25.7%, NNT=5) and LS (6g's, 402 participants, g=0.201, 95% CI=0.009, 0.394, P=0.04, Q=3.3, P=0.65, I2=0%, NNT=9) BMD. A trend for greater benefits in FN BMD was observed for studies published in countries other than the United States and for those who participated in home versus facility-based exercise. Statistically significant, or a trend for statistically significant, associations were observed for 7 different moderators and predictors, 6 for FN BMD and 1 for LS BMD. Conclusions. Exercise benefits FN and LS BMD in premenopausal women. The observed moderators and predictors deserve further investigation in well-designed randomized controlled trials. |
| format | Article |
| id | doaj-art-b890c14ed84445a4bad9ce99ce8375b8 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b890c14ed84445a4bad9ce99ce8375b82025-08-20T02:19:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/741639741639Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled TrialsGeorge A. Kelley0Kristi S. Kelley1Wendy M. Kohrt2Department of Community Medicine, West Virginia University, Morgantown, WV 26506, USADepartment of Community Medicine, West Virginia University, Morgantown, WV 26506, USADivision of Geriatric Medicine, University of Colorado Denver, Anschutz Medical Campus, P.O. Box 6511, Mail Stop B179, 12631 East 17th Avenue-L15, Aurora, CO 80045, USAObjective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women. Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and pooled using random-effects models, Z score alpha values, 95% confidence intervals (CIs), and number needed to treat (NNT). Heterogeneity was examined using Q and I2. Moderator and predictor analyses using mixed-effects ANOVA and simple metaregression were conducted. Statistical significance was set at P≤0.05. Results. Statistically significant improvements were found for both FN (7g's, 466 participants, g=0.342, 95% CI=0.132, 0.553, P=0.001, Q=10.8, P=0.22, I2=25.7%, NNT=5) and LS (6g's, 402 participants, g=0.201, 95% CI=0.009, 0.394, P=0.04, Q=3.3, P=0.65, I2=0%, NNT=9) BMD. A trend for greater benefits in FN BMD was observed for studies published in countries other than the United States and for those who participated in home versus facility-based exercise. Statistically significant, or a trend for statistically significant, associations were observed for 7 different moderators and predictors, 6 for FN BMD and 1 for LS BMD. Conclusions. Exercise benefits FN and LS BMD in premenopausal women. The observed moderators and predictors deserve further investigation in well-designed randomized controlled trials.http://dx.doi.org/10.1155/2013/741639 |
| spellingShingle | George A. Kelley Kristi S. Kelley Wendy M. Kohrt Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials International Journal of Endocrinology |
| title | Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials |
| title_full | Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials |
| title_short | Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials |
| title_sort | exercise and bone mineral density in premenopausal women a meta analysis of randomized controlled trials |
| url | http://dx.doi.org/10.1155/2013/741639 |
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