Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy.

We introduce a novel three-dimensional (3D) traction force microscopy (TFM) method motivated by the recent discovery that cells adhering on plane surfaces exert both in-plane and out-of-plane traction stresses. We measure the 3D deformation of the substratum on a thin layer near its surface, and inp...

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Bibliographic Details
Main Authors: Juan C del Álamo, Ruedi Meili, Begoña Álvarez-González, Baldomero Alonso-Latorre, Effie Bastounis, Richard Firtel, Juan C Lasheras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0069850
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