Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort

Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort

Abstract The glucocorticoid receptor (GR), particularly its isoforms GRα and GRβ, plays a crucial role in modulating inflammatory responses. The rs6198 single nucleotide polymorphism (SNP) in the NR3C1 gene, which encodes GR, has been associated with adverse outcomes in various diseases due to its p...

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Main Authors: Christoph Sombetzki, Lars Palmowski, Dominik Ziehe, Hartmuth Nowak, Tim Rahmel, Stefan Felix Ehrentraut, Patrick Thon, Jennifer Orlowski, Lars Bergmann, Michael Adamzik, Björn Koos, Katharina Rump, SepsisDataNet.NRW research group
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sepsis
Glucocorticoids
NR3C1
rs6198
Sepsis survival
Biomarker
Online Access:https://doi.org/10.1038/s41598-025-07398-4
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