Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics
Abstract The eXchange Unit between Thiolation domains approach and artificial intelligence (AI)‐driven tools like Synthetic Intelligence are transforming nonribosomal peptide synthetase and polyketide synthase engineering, enabling the creation of novel bioactive compounds that address critical chal...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.70146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850211156301447168 |
|---|---|
| author | Emre F. Bülbül Helge B. Bode Steven Schmitt Kenan A. J. Bozhüyük |
| author_facet | Emre F. Bülbül Helge B. Bode Steven Schmitt Kenan A. J. Bozhüyük |
| author_sort | Emre F. Bülbül |
| collection | DOAJ |
| description | Abstract The eXchange Unit between Thiolation domains approach and artificial intelligence (AI)‐driven tools like Synthetic Intelligence are transforming nonribosomal peptide synthetase and polyketide synthase engineering, enabling the creation of novel bioactive compounds that address critical challenges like antibiotic resistance and cancer. These innovations expand chemical space and optimize biosynthetic pathways, offering precise and scalable therapeutic solutions. Collaboration across synthetic biology, AI, and clinical research is essential to translating these breakthroughs into next‐generation treatments and revolutionizing drug discovery and patient care. |
| format | Article |
| id | doaj-art-b87fdfc879444e009642e9530a7c34e5 |
| institution | OA Journals |
| issn | 2001-1326 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj-art-b87fdfc879444e009642e9530a7c34e52025-08-20T02:09:37ZengWileyClinical and Translational Medicine2001-13262025-02-01152n/an/a10.1002/ctm2.70146Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeuticsEmre F. Bülbül0Helge B. Bode1Steven Schmitt2Kenan A. J. Bozhüyük3Synthetic Biology of Microbial Natural Products Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH) Saarbrücken GermanyDepartment of Natural Products in Organismic Interactions Max Planck Institute for Terrestrial Microbiology Marburg GermanyMyria Biosciences AG, Tech Park Basel Basel SwitzerlandSynthetic Biology of Microbial Natural Products Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), PharmaScienceHub (PSH) Saarbrücken GermanyAbstract The eXchange Unit between Thiolation domains approach and artificial intelligence (AI)‐driven tools like Synthetic Intelligence are transforming nonribosomal peptide synthetase and polyketide synthase engineering, enabling the creation of novel bioactive compounds that address critical challenges like antibiotic resistance and cancer. These innovations expand chemical space and optimize biosynthetic pathways, offering precise and scalable therapeutic solutions. Collaboration across synthetic biology, AI, and clinical research is essential to translating these breakthroughs into next‐generation treatments and revolutionizing drug discovery and patient care.https://doi.org/10.1002/ctm2.70146AIbioengineeringnatural productssynthetic biology |
| spellingShingle | Emre F. Bülbül Helge B. Bode Steven Schmitt Kenan A. J. Bozhüyük Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics Clinical and Translational Medicine AI bioengineering natural products synthetic biology |
| title | Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics |
| title_full | Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics |
| title_fullStr | Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics |
| title_full_unstemmed | Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics |
| title_short | Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics |
| title_sort | engineering the future of medicine natural products synthetic biology and artificial intelligence for next generation therapeutics |
| topic | AI bioengineering natural products synthetic biology |
| url | https://doi.org/10.1002/ctm2.70146 |
| work_keys_str_mv | AT emrefbulbul engineeringthefutureofmedicinenaturalproductssyntheticbiologyandartificialintelligencefornextgenerationtherapeutics AT helgebbode engineeringthefutureofmedicinenaturalproductssyntheticbiologyandartificialintelligencefornextgenerationtherapeutics AT stevenschmitt engineeringthefutureofmedicinenaturalproductssyntheticbiologyandartificialintelligencefornextgenerationtherapeutics AT kenanajbozhuyuk engineeringthefutureofmedicinenaturalproductssyntheticbiologyandartificialintelligencefornextgenerationtherapeutics |