Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis
Background Iron metabolism plays a significant role in the development of metabolic disorders in women with polycystic ovary syndrome (PCOS). Despite the importance of hepcidin, a key iron regulator, current research on serum hepcidin levels in PCOS patients shows conflicting results.Methods PubMed,...
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Taylor & Francis Group
2024-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2024.2375568 |
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| author | Jieou Nong Hua Li Yunfei Yang Qiujie Lu Yifan Sun Qi Yin Hongying He |
| author_facet | Jieou Nong Hua Li Yunfei Yang Qiujie Lu Yifan Sun Qi Yin Hongying He |
| author_sort | Jieou Nong |
| collection | DOAJ |
| description | Background Iron metabolism plays a significant role in the development of metabolic disorders in women with polycystic ovary syndrome (PCOS). Despite the importance of hepcidin, a key iron regulator, current research on serum hepcidin levels in PCOS patients shows conflicting results.Methods PubMed, Embase, Web of Science, Cochrane Library and the China National Knowledge Infrastructure (CNKI) database were systematically searched from their inception to 9 September 2023. The search aimed to identify studies in English and Chinese that examined hepcidin levels in women with PCOS compared to healthy control subjects. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (95% CIs) were calculated to evaluate the difference in serum hepcidin levels between women with and without PCOS.Results The meta-analysis included a total of 10 eligible studies, which encompassed 499 PCOS patients and 391 control subjects. The pooled analysis revealed a significant reduction in serum hepcidin levels among the PCOS patients compared to the healthy controls (SMD = −3.49, 95% CI: −4.68 to −2.30, p < .05). There was no statistically significant difference in serum hepcidin levels between PCOS patients with a body mass index (BMI) < 25 and those with a BMI ≥ 25 (p > .05).Conclusion The serum hepcidin levels of women with PCOS were significantly lower than those of healthy controls, which suggests that serum hepcidin could be a potential biomarker for PCOS. |
| format | Article |
| id | doaj-art-b87fa919b64744a4a3b89ed46b9938cd |
| institution | DOAJ |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Gynecological Endocrinology |
| spelling | doaj-art-b87fa919b64744a4a3b89ed46b9938cd2025-08-20T02:39:22ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662024-12-0140110.1080/09513590.2024.2375568Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysisJieou Nong0Hua Li1Yunfei Yang2Qiujie Lu3Yifan Sun4Qi Yin5Hongying He6Department of Clinical Laboratory, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang City People’s Hospital, Guigang, Guangxi, ChinaDepartment of Clinical Laboratory, Liuzhou Municipal Liutie Central Hospital, Liuzhou, ChinaDepartment of Gynecology, Liuzhou Municipal Liutie Central Hospital, Liuzhou, ChinaBackground Iron metabolism plays a significant role in the development of metabolic disorders in women with polycystic ovary syndrome (PCOS). Despite the importance of hepcidin, a key iron regulator, current research on serum hepcidin levels in PCOS patients shows conflicting results.Methods PubMed, Embase, Web of Science, Cochrane Library and the China National Knowledge Infrastructure (CNKI) database were systematically searched from their inception to 9 September 2023. The search aimed to identify studies in English and Chinese that examined hepcidin levels in women with PCOS compared to healthy control subjects. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (95% CIs) were calculated to evaluate the difference in serum hepcidin levels between women with and without PCOS.Results The meta-analysis included a total of 10 eligible studies, which encompassed 499 PCOS patients and 391 control subjects. The pooled analysis revealed a significant reduction in serum hepcidin levels among the PCOS patients compared to the healthy controls (SMD = −3.49, 95% CI: −4.68 to −2.30, p < .05). There was no statistically significant difference in serum hepcidin levels between PCOS patients with a body mass index (BMI) < 25 and those with a BMI ≥ 25 (p > .05).Conclusion The serum hepcidin levels of women with PCOS were significantly lower than those of healthy controls, which suggests that serum hepcidin could be a potential biomarker for PCOS.https://www.tandfonline.com/doi/10.1080/09513590.2024.2375568Polycystic ovary syndromehepcidiniron metabolismmeta-analysis |
| spellingShingle | Jieou Nong Hua Li Yunfei Yang Qiujie Lu Yifan Sun Qi Yin Hongying He Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis Gynecological Endocrinology Polycystic ovary syndrome hepcidin iron metabolism meta-analysis |
| title | Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis |
| title_full | Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis |
| title_fullStr | Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis |
| title_full_unstemmed | Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis |
| title_short | Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis |
| title_sort | low serum hepcidin levels in women with polycystic ovary syndrome evidence from meta analysis |
| topic | Polycystic ovary syndrome hepcidin iron metabolism meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2024.2375568 |
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