Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease
It is well-established that Morus alba and its derivatives have been clinically proven to have antioxidant and anti-inflammatory properties. Although several studies have mentioned the beneficial effect of Morus alba on kidney disorders, the role of Morus alba in CKD still needs to be explored. Thus...
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Taylor & Francis Group
2024-12-01
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| Series: | Cogent Food & Agriculture |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/23311932.2024.2301841 |
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| author | Ahmad Fauzi Nurina Titisari Mohd. Hezmee Mohd. Noor Azrina Azlan Hazilawati Hamzah |
| author_facet | Ahmad Fauzi Nurina Titisari Mohd. Hezmee Mohd. Noor Azrina Azlan Hazilawati Hamzah |
| author_sort | Ahmad Fauzi |
| collection | DOAJ |
| description | It is well-established that Morus alba and its derivatives have been clinically proven to have antioxidant and anti-inflammatory properties. Although several studies have mentioned the beneficial effect of Morus alba on kidney disorders, the role of Morus alba in CKD still needs to be explored. Thus, this study investigated the effect of Morus alba and chlorogenic acid treatment on renal fibrosis in mice induced with unilateral urethral obstruction (UUO). Twenty-five Balb/c mice were randomly divided into five groups: the sham-operated group, the UUO untreated group, and the UUO treated with enalapril (ENA), Morus alba leaves extract (MLE) and chlorogenic acid (CGA) groups. Urine, blood, and organ samples were collected to evaluate urinalysis, haematology, biochemistry, and histopathology. The result indicated that the UUO group had significantly higher levels of creatinine (p < 0.001) and urea (p < 0.05), as well as hydronephrosis and urine crystal sedimentation (p < 0.05). In comparison to the UUO group, the MLE and CGA groups displayed improved urine profiles, ameliorated anaemia (p < 0.05), and urine crystals (p < 0.05). The administration of CGA also significantly reduced serum creatinine (p < 0.05) and protein-creatinine ratio (UPCr) levels. In addition, MLE and CGA could prevent hydronephrosis and delay renal damage, particularly in the dilation of Bowman’s space, tubular injury, loss of tubular epithelium, and cellular inflammation. In conclusion, Morus alba and CGA had a therapeutic effect in minimising the progression of renal damage. As a result, it can be promoted as a complementary renoprotective product based on natural products, as it has a potentially similar effect to enalapril. |
| format | Article |
| id | doaj-art-b87c807476ad4a7ca623e56c239ac814 |
| institution | OA Journals |
| issn | 2331-1932 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Food & Agriculture |
| spelling | doaj-art-b87c807476ad4a7ca623e56c239ac8142025-08-20T02:38:14ZengTaylor & Francis GroupCogent Food & Agriculture2331-19322024-12-0110110.1080/23311932.2024.2301841Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney diseaseAhmad Fauzi0Nurina Titisari1Mohd. Hezmee Mohd. Noor2Azrina Azlan3Hazilawati Hamzah4Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, MalaysiaDepartment of Veterinary Physiology, Faculty of Veterinary Medicine, University of Brawijaya, Malang, IndonesiaDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, MalaysiaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, MalaysiaIt is well-established that Morus alba and its derivatives have been clinically proven to have antioxidant and anti-inflammatory properties. Although several studies have mentioned the beneficial effect of Morus alba on kidney disorders, the role of Morus alba in CKD still needs to be explored. Thus, this study investigated the effect of Morus alba and chlorogenic acid treatment on renal fibrosis in mice induced with unilateral urethral obstruction (UUO). Twenty-five Balb/c mice were randomly divided into five groups: the sham-operated group, the UUO untreated group, and the UUO treated with enalapril (ENA), Morus alba leaves extract (MLE) and chlorogenic acid (CGA) groups. Urine, blood, and organ samples were collected to evaluate urinalysis, haematology, biochemistry, and histopathology. The result indicated that the UUO group had significantly higher levels of creatinine (p < 0.001) and urea (p < 0.05), as well as hydronephrosis and urine crystal sedimentation (p < 0.05). In comparison to the UUO group, the MLE and CGA groups displayed improved urine profiles, ameliorated anaemia (p < 0.05), and urine crystals (p < 0.05). The administration of CGA also significantly reduced serum creatinine (p < 0.05) and protein-creatinine ratio (UPCr) levels. In addition, MLE and CGA could prevent hydronephrosis and delay renal damage, particularly in the dilation of Bowman’s space, tubular injury, loss of tubular epithelium, and cellular inflammation. In conclusion, Morus alba and CGA had a therapeutic effect in minimising the progression of renal damage. As a result, it can be promoted as a complementary renoprotective product based on natural products, as it has a potentially similar effect to enalapril.https://www.tandfonline.com/doi/10.1080/23311932.2024.2301841Morus alba leafchlorogenic acidhydronephroticurine crystalrenal damagePedro González-Redondo, University of Seville, Seville, Spain |
| spellingShingle | Ahmad Fauzi Nurina Titisari Mohd. Hezmee Mohd. Noor Azrina Azlan Hazilawati Hamzah Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease Cogent Food & Agriculture Morus alba leaf chlorogenic acid hydronephrotic urine crystal renal damage Pedro González-Redondo, University of Seville, Seville, Spain |
| title | Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| title_full | Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| title_fullStr | Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| title_full_unstemmed | Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| title_short | Therapeutic effect of Morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| title_sort | therapeutic effect of morus alba leaf extract and chlorogenic acid on inhibiting the progression of kidney disease |
| topic | Morus alba leaf chlorogenic acid hydronephrotic urine crystal renal damage Pedro González-Redondo, University of Seville, Seville, Spain |
| url | https://www.tandfonline.com/doi/10.1080/23311932.2024.2301841 |
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