Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment
The all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill. Among the various agricultural and industrial by-products, residues from winem...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1620087/full |
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| author | Wanting Chen Wanting Chen Preeti Pandey Zyta M. Ziora Zyta M. Ziora Anjana Jayasree Anjana Jayasree Harendra S. Parekh Harendra S. Parekh |
| author_facet | Wanting Chen Wanting Chen Preeti Pandey Zyta M. Ziora Zyta M. Ziora Anjana Jayasree Anjana Jayasree Harendra S. Parekh Harendra S. Parekh |
| author_sort | Wanting Chen |
| collection | DOAJ |
| description | The all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill. Among the various agricultural and industrial by-products, residues from winemaking stand out for their exceptionally rich and diverse bioactive compound content, primarily originating from grape skins, seeds and stems, all of which are rich in polyphenols, organic acids and tannins. These compounds have remarkable antioxidant, antimicrobial and anti-inflammatory properties and can therefore be diverted to agricultural, food preservation, cosmetic and pharmaceutical industries. The mechanism of action of the array of bioactive compounds includes disruption of microbial cell membranes, reduction of oxidative stress, and modulation of inflammatory responses. The current literature is limited to highlights of the scale of waste generated, and the application of its bioactive agents, however, it is notably absent of critical appraisal and discussion in sustainable avenues for development and value-added products, which are comprehensively elaborated herein. |
| format | Article |
| id | doaj-art-b87afe7415214d15a907ebd0afd91e2c |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b87afe7415214d15a907ebd0afd91e2c2025-08-26T05:28:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.16200871620087Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatmentWanting Chen0Wanting Chen1Preeti Pandey2Zyta M. Ziora3Zyta M. Ziora4Anjana Jayasree5Anjana Jayasree6Harendra S. Parekh7Harendra S. Parekh8School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, QLD, AustraliaARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR), The University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, QLD, AustraliaARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR), The University of Queensland, Brisbane, QLD, AustraliaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, QLD, AustraliaARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR), The University of Queensland, Brisbane, QLD, AustraliaSchool of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, QLD, AustraliaARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEA-StAR), The University of Queensland, Brisbane, QLD, AustraliaThe all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill. Among the various agricultural and industrial by-products, residues from winemaking stand out for their exceptionally rich and diverse bioactive compound content, primarily originating from grape skins, seeds and stems, all of which are rich in polyphenols, organic acids and tannins. These compounds have remarkable antioxidant, antimicrobial and anti-inflammatory properties and can therefore be diverted to agricultural, food preservation, cosmetic and pharmaceutical industries. The mechanism of action of the array of bioactive compounds includes disruption of microbial cell membranes, reduction of oxidative stress, and modulation of inflammatory responses. The current literature is limited to highlights of the scale of waste generated, and the application of its bioactive agents, however, it is notably absent of critical appraisal and discussion in sustainable avenues for development and value-added products, which are comprehensively elaborated herein.https://www.frontiersin.org/articles/10.3389/fphar.2025.1620087/fullwine by-productsantimicrobialanimal skin infectionspolyphenolsantimicrobial resistanceanimal healthcare applications |
| spellingShingle | Wanting Chen Wanting Chen Preeti Pandey Zyta M. Ziora Zyta M. Ziora Anjana Jayasree Anjana Jayasree Harendra S. Parekh Harendra S. Parekh Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment Frontiers in Pharmacology wine by-products antimicrobial animal skin infections polyphenols antimicrobial resistance animal healthcare applications |
| title | Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment |
| title_full | Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment |
| title_fullStr | Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment |
| title_full_unstemmed | Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment |
| title_short | Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment |
| title_sort | grape by products from the wine industry an untapped sustainable resource for application in animal skin health preservation and treatment |
| topic | wine by-products antimicrobial animal skin infections polyphenols antimicrobial resistance animal healthcare applications |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1620087/full |
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