Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo
Background: Bruguiera gymnorrhiza mangrove and propolis are often used as natural wound treatments. Its constituent is believed to promote wound healing. Objective: This study aims to explore the effect of topical administration of ethanol extract of Bruguiera gymnorrhiza mangrove leaves and pro...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2022-07-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/94 |
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| author | Evi Kurniawaty Shina Megaputri Syazili Mustofa Soraya Rahmanisa Kholis Abdurachim Audah Silvia Andriani |
| author_facet | Evi Kurniawaty Shina Megaputri Syazili Mustofa Soraya Rahmanisa Kholis Abdurachim Audah Silvia Andriani |
| author_sort | Evi Kurniawaty |
| collection | DOAJ |
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Background: Bruguiera gymnorrhiza mangrove and propolis are often used as natural wound treatments. Its constituent is believed to promote wound healing.
Objective: This study aims to explore the effect of topical administration of ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis on wound healing activity.
Methods: Twenty-four Sprague Dawley rats were randomly assigned to one of four treatment groups (n=6): aqua dest, standard wound medicine, ethanol extract of Bruguiera gymnorrhiza mangrove leaves, and propolis extract. Following the incision, treatment was given once a day for 14 days or until the wound healed. The cut area was observed by measuring the cut length using a ruler.
Results: Standard wound medication took 9 days to promote healing, while the negative control (aqua dest) took 11.2 days, the ethanol extract of Bruguiera gymnorrhiza mangrove leaves took 7.3 days, and the propolis extract took 7.9 days.
Conclusions: Topical administration of Bruguiera gymnorrhiza mangrove leaves ethanol extract and propolis had equal effects on the healing of wounds. Both are more effective than conventional wound ointments at healing cuts.
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| format | Article |
| id | doaj-art-b873d95c311b46a6858e230856eafad3 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-b873d95c311b46a6858e230856eafad32025-02-08T03:06:02ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-07-015110.32889/actabioina.94Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivoEvi Kurniawaty0Shina Megaputri1Syazili Mustofa2Soraya Rahmanisa3Kholis Abdurachim Audah4Silvia Andriani5Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Lampung, Lampung, 35141, IndonesiaDepartment of Biochemistry and Biomolecular, Faculty of Medicine, University of Lampung, Lampung, 35141, IndonesiaDepartment of Biochemistry and Biomolecular, Faculty of Medicine, University of Lampung, Lampung, 35141, IndonesiaDepartment of Biochemistry and Biomolecular, Faculty of Medicine, University of Lampung, Lampung, 35141, IndonesiaDepartment of Biomedical Engineering, Faculty of Life Sciences and Technology, Swiss German University, Tangerang, IndonesiaDepartement of Biology, Faculty of Mathematics and Natural Sciences, University of Lampung, 35141, Indonesia Background: Bruguiera gymnorrhiza mangrove and propolis are often used as natural wound treatments. Its constituent is believed to promote wound healing. Objective: This study aims to explore the effect of topical administration of ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis on wound healing activity. Methods: Twenty-four Sprague Dawley rats were randomly assigned to one of four treatment groups (n=6): aqua dest, standard wound medicine, ethanol extract of Bruguiera gymnorrhiza mangrove leaves, and propolis extract. Following the incision, treatment was given once a day for 14 days or until the wound healed. The cut area was observed by measuring the cut length using a ruler. Results: Standard wound medication took 9 days to promote healing, while the negative control (aqua dest) took 11.2 days, the ethanol extract of Bruguiera gymnorrhiza mangrove leaves took 7.3 days, and the propolis extract took 7.9 days. Conclusions: Topical administration of Bruguiera gymnorrhiza mangrove leaves ethanol extract and propolis had equal effects on the healing of wounds. Both are more effective than conventional wound ointments at healing cuts. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/94Bruguiera gymnorrhizapropoliswound healing |
| spellingShingle | Evi Kurniawaty Shina Megaputri Syazili Mustofa Soraya Rahmanisa Kholis Abdurachim Audah Silvia Andriani Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo Acta Biochimica Indonesiana Bruguiera gymnorrhiza propolis wound healing |
| title | Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| title_full | Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| title_fullStr | Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| title_full_unstemmed | Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| title_short | Ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| title_sort | ethanol extract of bruguiera gymnorrhiza mangrove leaves and propolis activity on macroscopic healing of cuts in vivo |
| topic | Bruguiera gymnorrhiza propolis wound healing |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/94 |
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