Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis
Abstract While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | https://doi.org/10.1186/s13024-025-00847-8 |
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| _version_ | 1849311981636419584 |
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| author | John Hardy Patrick Lewis |
| author_facet | John Hardy Patrick Lewis |
| author_sort | John Hardy |
| collection | DOAJ |
| description | Abstract While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed. |
| format | Article |
| id | doaj-art-b871e552f29047bdb7c5e42e28b0a142 |
| institution | Kabale University |
| issn | 1750-1326 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj-art-b871e552f29047bdb7c5e42e28b0a1422025-08-20T03:53:13ZengBMCMolecular Neurodegeneration1750-13262025-05-012011310.1186/s13024-025-00847-8Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesisJohn Hardy0Patrick Lewis1Department of Neurodegenerative Disease, UCL Institute of NeurologyDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of LondonAbstract While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.https://doi.org/10.1186/s13024-025-00847-8 |
| spellingShingle | John Hardy Patrick Lewis Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis Molecular Neurodegeneration |
| title | Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis |
| title_full | Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis |
| title_fullStr | Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis |
| title_full_unstemmed | Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis |
| title_short | Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis |
| title_sort | evidence suggesting that microglia make amyloid from neuronally expressed app a hypothesis |
| url | https://doi.org/10.1186/s13024-025-00847-8 |
| work_keys_str_mv | AT johnhardy evidencesuggestingthatmicrogliamakeamyloidfromneuronallyexpressedappahypothesis AT patricklewis evidencesuggestingthatmicrogliamakeamyloidfromneuronallyexpressedappahypothesis |