Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage
Background. The Pakistani population has higher incidence of cardiovascular (CV) diseases at younger ages, due to undiagnosed, uncontrolled hypertension (HTN). A variety of associated HTN stressors is also reported. The study plans to understand the variables associated with initiation of HTN in thi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/906327 |
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| author | Sadiqa Badar Syed Masood Anwar Qureshi |
| author_facet | Sadiqa Badar Syed Masood Anwar Qureshi |
| author_sort | Sadiqa Badar Syed |
| collection | DOAJ |
| description | Background. The Pakistani population has higher incidence of cardiovascular (CV) diseases at younger ages, due to undiagnosed, uncontrolled hypertension (HTN). A variety of associated HTN stressors is also reported. The study plans to understand the variables associated with initiation of HTN in this population.
Objective. To find plasma aldosterone and cortisol relationship with some CV risk factors (obesity, dyslipidemia, hyperglycemia, sodium and potassium) in different stages of HTN particularly prehypertension. Subjects and Methods. The study conducted on 276 subjects (25–60 years), classified into prehypertensive (𝑛=55), HTN stage-1 (𝑛=70) and II (𝑛=76) according to 7th JNC report and compared with normotensive controls (𝑛=75). The anthropometric profiles (height, weight, waist circumference, Body Mass index) and BP recorded. Serum cortisol, aldosterone, total cholesterol, Low density lipoproteins, blood glucose, Na+ and K+, using standard laboratory techniques, were determined in fasting blood samples. Results. Subjects were mostly overweight and obese (80%, 90%, and 76% in pre-HTN, stage-I and II versus 69% in controls). The aldosterone level (ng/dl) was in higher normal range (9.17–12.41) and significantly correlated to BMI (0.587) in controls, and to TC (0.726) and LDL (0.620) in pre-HTN stage-I. The cortisol level was positively correlated (𝑃<0.01) to BMI (0.538), Na+ (0.690) and K+ (0.578) in control, and to BMI (0.628) and WC (0.679) in pre-HTN group, showing its association with BMI>25.
Conclusion. Pre-HTN stage among Pakistani population with successive increase in various risk factors of HTN in relation to aldosterone and cortisol has been identified. Interaction of the risk factors with endogenous levels of these hormones may initiate stages of HTN. |
| format | Article |
| id | doaj-art-b870d85af99d41b7b8a4bc95cc458d68 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b870d85af99d41b7b8a4bc95cc458d682025-02-03T06:07:59ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/906327906327Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension StageSadiqa Badar Syed0Masood Anwar Qureshi1Department of Physiology, Medical and Dental College, Bahria University, Karachi 75260, PakistanDepartment of Physiology, Dow University of Health Sciences, Karachi 74200, PakistanBackground. The Pakistani population has higher incidence of cardiovascular (CV) diseases at younger ages, due to undiagnosed, uncontrolled hypertension (HTN). A variety of associated HTN stressors is also reported. The study plans to understand the variables associated with initiation of HTN in this population. Objective. To find plasma aldosterone and cortisol relationship with some CV risk factors (obesity, dyslipidemia, hyperglycemia, sodium and potassium) in different stages of HTN particularly prehypertension. Subjects and Methods. The study conducted on 276 subjects (25–60 years), classified into prehypertensive (𝑛=55), HTN stage-1 (𝑛=70) and II (𝑛=76) according to 7th JNC report and compared with normotensive controls (𝑛=75). The anthropometric profiles (height, weight, waist circumference, Body Mass index) and BP recorded. Serum cortisol, aldosterone, total cholesterol, Low density lipoproteins, blood glucose, Na+ and K+, using standard laboratory techniques, were determined in fasting blood samples. Results. Subjects were mostly overweight and obese (80%, 90%, and 76% in pre-HTN, stage-I and II versus 69% in controls). The aldosterone level (ng/dl) was in higher normal range (9.17–12.41) and significantly correlated to BMI (0.587) in controls, and to TC (0.726) and LDL (0.620) in pre-HTN stage-I. The cortisol level was positively correlated (𝑃<0.01) to BMI (0.538), Na+ (0.690) and K+ (0.578) in control, and to BMI (0.628) and WC (0.679) in pre-HTN group, showing its association with BMI>25. Conclusion. Pre-HTN stage among Pakistani population with successive increase in various risk factors of HTN in relation to aldosterone and cortisol has been identified. Interaction of the risk factors with endogenous levels of these hormones may initiate stages of HTN.http://dx.doi.org/10.1155/2012/906327 |
| spellingShingle | Sadiqa Badar Syed Masood Anwar Qureshi Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage International Journal of Hypertension |
| title | Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage |
| title_full | Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage |
| title_fullStr | Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage |
| title_full_unstemmed | Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage |
| title_short | Association of Aldosterone and Cortisol with Cardiovascular Risk Factors in Prehypertension Stage |
| title_sort | association of aldosterone and cortisol with cardiovascular risk factors in prehypertension stage |
| url | http://dx.doi.org/10.1155/2012/906327 |
| work_keys_str_mv | AT sadiqabadarsyed associationofaldosteroneandcortisolwithcardiovascularriskfactorsinprehypertensionstage AT masoodanwarqureshi associationofaldosteroneandcortisolwithcardiovascularriskfactorsinprehypertensionstage |