Cystathionine γ-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle

Cystathionine γ-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle

Objective Chronic liver diseases (CLDs) are prevalent globally. The purpose of the current study was to elucidate the regulatory mechanisms underlying the pathophysiological processes in CLDs.Methods and Results Using the GEO database, we identified cysteine and methionine metabolism as a commonly e...

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Bibliographic Details
Main Authors: Cichun Wu, Wei Zhang, Wenhu Liu, Zhengshan Tang, Shifang Peng, Lei Fu, Xin Ni
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Redox Report
Subjects:
Cystathionine γ-lyase
necroptosis
mitochondria
histone lysine methylation
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2025.2531650
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