Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions
Short-chain fatty acids (SCFAs), pivotal metabolites derived from microbial fermentation of dietary fiber, serve as critical modulators of glucose and lipid metabolism. Dysregulation of SCFA levels, often stemming from inadequate fiber intake or dysbiosis of SCFA-producing microbiota, correlates wit...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/jnme/8870958 |
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| author | Yueru Zhao Jing Chen Yunlong Qin Jinguo Yuan Zixian Yu Rui Ma Fude Liu Jin Zhao |
| author_facet | Yueru Zhao Jing Chen Yunlong Qin Jinguo Yuan Zixian Yu Rui Ma Fude Liu Jin Zhao |
| author_sort | Yueru Zhao |
| collection | DOAJ |
| description | Short-chain fatty acids (SCFAs), pivotal metabolites derived from microbial fermentation of dietary fiber, serve as critical modulators of glucose and lipid metabolism. Dysregulation of SCFA levels, often stemming from inadequate fiber intake or dysbiosis of SCFA-producing microbiota, correlates with heightened susceptibility to diverse pathologies, including autoimmune disorders, metabolic syndromes, and malignancies. Emerging evidence underscores the pleiotropic roles of SCFAs in orchestrating gut and systemic homeostasis, positioning them as novel therapeutic candidates for immune dysregulation, inflammatory conditions, and transplant rejection. This review synthesizes current knowledge on SCFA biosynthesis, absorption dynamics, and their multifaceted regulatory mechanisms, spanning epigenetic modulation, G protein–coupled receptor (GPR) signaling, and immune cell crosstalk. We further elucidate their therapeutic potential in clinical contexts, emphasizing their capacity to recalibrate immune responses, suppress chronic inflammation, and mitigate oncogenesis. By integrating recent advances in microbiome research and translational applications, this work highlights the imperative for precision interventions targeting SCFA pathways to bridge the gap between microbial ecology and clinical innovation. |
| format | Article |
| id | doaj-art-b86c240fa6b7440fa6f85012a576bccf |
| institution | Kabale University |
| issn | 2090-0732 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-b86c240fa6b7440fa6f85012a576bccf2025-08-20T04:00:40ZengWileyJournal of Nutrition and Metabolism2090-07322025-01-01202510.1155/jnme/8870958Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future DirectionsYueru Zhao0Jing Chen1Yunlong Qin2Jinguo Yuan3Zixian Yu4Rui Ma5Fude Liu6Jin Zhao7School of Clinical MedicineDepartment of NeurosurgeryDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of GeriatricsDepartment of NeurologyDepartment of NephrologyShort-chain fatty acids (SCFAs), pivotal metabolites derived from microbial fermentation of dietary fiber, serve as critical modulators of glucose and lipid metabolism. Dysregulation of SCFA levels, often stemming from inadequate fiber intake or dysbiosis of SCFA-producing microbiota, correlates with heightened susceptibility to diverse pathologies, including autoimmune disorders, metabolic syndromes, and malignancies. Emerging evidence underscores the pleiotropic roles of SCFAs in orchestrating gut and systemic homeostasis, positioning them as novel therapeutic candidates for immune dysregulation, inflammatory conditions, and transplant rejection. This review synthesizes current knowledge on SCFA biosynthesis, absorption dynamics, and their multifaceted regulatory mechanisms, spanning epigenetic modulation, G protein–coupled receptor (GPR) signaling, and immune cell crosstalk. We further elucidate their therapeutic potential in clinical contexts, emphasizing their capacity to recalibrate immune responses, suppress chronic inflammation, and mitigate oncogenesis. By integrating recent advances in microbiome research and translational applications, this work highlights the imperative for precision interventions targeting SCFA pathways to bridge the gap between microbial ecology and clinical innovation.http://dx.doi.org/10.1155/jnme/8870958 |
| spellingShingle | Yueru Zhao Jing Chen Yunlong Qin Jinguo Yuan Zixian Yu Rui Ma Fude Liu Jin Zhao Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions Journal of Nutrition and Metabolism |
| title | Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions |
| title_full | Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions |
| title_fullStr | Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions |
| title_full_unstemmed | Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions |
| title_short | Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions |
| title_sort | linking short chain fatty acids to systemic homeostasis mechanisms therapeutic potential and future directions |
| url | http://dx.doi.org/10.1155/jnme/8870958 |
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