Generating tumor-specific T cells based on a head and neck cancer organoid for adoptive cell therapy

Generating tumor-specific T cells based on a head and neck cancer organoid for adoptive cell therapy

BackgroundA head and neck cancer organoid (HNCO) and peripheral blood T cell co-culture model was established to investigate whether HNCOs can induce the differentiation of peripheral blood T cells into tumor-reactive T cells. Additionally, this study seeks to explore the cytotoxicity of these T cel...

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Bibliographic Details
Main Authors: Yinyu Chen, Shoupeng Wang, Luxi Zheng, Lin Chen, Feng Xu, Shuqi Guo, Jian Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
adoptive cell therapy
peripheral blood T cells
head and neck cancer
organoid
co-culture
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1573965/full
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