Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation
Early hearing deprivation could affect the development of auditory, language, and vision ability. Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development. Twenty-three infants with congeni...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/8986362 |
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| _version_ | 1832547598325514240 |
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| author | Shuang Xia TianBin Song Jing Che Qiang Li Chao Chai Meizhu Zheng Wen Shen |
| author_facet | Shuang Xia TianBin Song Jing Che Qiang Li Chao Chai Meizhu Zheng Wen Shen |
| author_sort | Shuang Xia |
| collection | DOAJ |
| description | Early hearing deprivation could affect the development of auditory, language, and vision ability. Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development. Twenty-three infants with congenital severe sensorineural hearing loss (CSSHL) and 17 age and sex matched normal hearing subjects were recruited. The amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) of the auditory, language, and vision related brain areas were compared between deaf infants and normal subjects. Compared with normal hearing subjects, decreased ALFF and ReHo were observed in auditory and language-related cortex. Increased ALFF and ReHo were observed in vision related cortex, which suggest that hearing and language function were impaired and vision function was enhanced due to the loss of hearing. ALFF of left Brodmann area 45 (BA45) was negatively correlated with deaf duration in infants with CSSHL. ALFF of right BA39 was positively correlated with deaf duration in infants with CSSHL. In conclusion, ALFF and ReHo can reflect the abnormal brain function in language, auditory, and visual information processing in infants with CSSHL. This demonstrates that the development of auditory, language, and vision processing function has been affected by congenital severe sensorineural hearing loss before 4 years of age. |
| format | Article |
| id | doaj-art-b865b0956c6c46558697112ef5f0c69a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b865b0956c6c46558697112ef5f0c69a2025-02-03T06:44:21ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/89863628986362Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under SedationShuang Xia0TianBin Song1Jing Che2Qiang Li3Chao Chai4Meizhu Zheng5Wen Shen6Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, ChinaDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Ultrasound, Aerospace Central Hospital, Beijing 100049, ChinaSchool of Law and Politics, Tianjin University of Technology, Tianjin 300384, ChinaDepartment of Radiology, Tianjin First Central Hospital, Tianjin 300192, ChinaDepartment of Radiology, Tianjin Third Central Hospital, Tianjin 300172, ChinaDepartment of Radiology, Tianjin First Central Hospital, Tianjin 300192, ChinaEarly hearing deprivation could affect the development of auditory, language, and vision ability. Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development. Twenty-three infants with congenital severe sensorineural hearing loss (CSSHL) and 17 age and sex matched normal hearing subjects were recruited. The amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) of the auditory, language, and vision related brain areas were compared between deaf infants and normal subjects. Compared with normal hearing subjects, decreased ALFF and ReHo were observed in auditory and language-related cortex. Increased ALFF and ReHo were observed in vision related cortex, which suggest that hearing and language function were impaired and vision function was enhanced due to the loss of hearing. ALFF of left Brodmann area 45 (BA45) was negatively correlated with deaf duration in infants with CSSHL. ALFF of right BA39 was positively correlated with deaf duration in infants with CSSHL. In conclusion, ALFF and ReHo can reflect the abnormal brain function in language, auditory, and visual information processing in infants with CSSHL. This demonstrates that the development of auditory, language, and vision processing function has been affected by congenital severe sensorineural hearing loss before 4 years of age.http://dx.doi.org/10.1155/2017/8986362 |
| spellingShingle | Shuang Xia TianBin Song Jing Che Qiang Li Chao Chai Meizhu Zheng Wen Shen Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation Neural Plasticity |
| title | Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation |
| title_full | Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation |
| title_fullStr | Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation |
| title_full_unstemmed | Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation |
| title_short | Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation |
| title_sort | altered brain functional activity in infants with congenital bilateral severe sensorineural hearing loss a resting state functional mri study under sedation |
| url | http://dx.doi.org/10.1155/2017/8986362 |
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