Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cel...
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Japan Surgical Society
2020-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-01041-2 |
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| author | Takuya Yamamoto Tomoyuki Abe Akihiko Oshita Shuji Yonehara Yoshio Katamura Nozomu Matsumoto Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_facet | Takuya Yamamoto Tomoyuki Abe Akihiko Oshita Shuji Yonehara Yoshio Katamura Nozomu Matsumoto Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_sort | Takuya Yamamoto |
| collection | DOAJ |
| description | Abstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cell type ICC following laparoscopic hepatectomy. Case presentation A 67-year-old woman had a history of hepatitis B virus. Computed tomography revealed a ring-like enhanced mass 35 mm in diameter at segment 7 in the early phase. The enhancement was prolonged to the late phase through the portal phase, while the shape was irregular. Ethoxybenzy magnetic resonance imaging revealed that the tumor had a low signal intensity on T1-weighted imaging and a high signal intensity on T2-weighted imaging. Diffusion-weighted images identified that the tumor had remarkably high signal intensity. Tumor enhancement was not detected throughout the tumor in the hepatocyte phase. Upon ICC diagnosis, a laparoscopic S7 subsegmentectomy was performed. The patient’s postoperative course was uneventful. An immunohistochemical examination revealed that the cells tested positive for cytokeratin 7 (CK7), CK19, and CD56 and negative for CK20, CD10, α-fetoprotein, thyroid transcription factor-1. At 2 years after surgery, the patient remains alive without recurrence. Conclusions Here we presented a case of clear cell ICC that was treated by laparoscopic hepatectomy. Immunological analysis, especially by CD56 and several CK markers, is helpful for diagnosing this disease. |
| format | Article |
| id | doaj-art-b85ff20a103f485c96452b167fdfab92 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-b85ff20a103f485c96452b167fdfab922025-08-20T03:39:26ZengJapan Surgical SocietySurgical Case Reports2198-77932020-10-01611510.1186/s40792-020-01041-2Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgeryTakuya Yamamoto0Tomoyuki Abe1Akihiko Oshita2Shuji Yonehara3Yoshio Katamura4Nozomu Matsumoto5Tsuyoshi Kobayashi6Masahiro Nakahara7Hideki Ohdan8Toshio Noriyuki9Department of Gastroenterology, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Pathology, Onomichi General HospitalDepartment of Gastroenterology, Onomichi General HospitalDepartment of Gastroenterology, Onomichi General HospitalDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Surgery, Onomichi General HospitalDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Surgery, Onomichi General HospitalAbstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cell type ICC following laparoscopic hepatectomy. Case presentation A 67-year-old woman had a history of hepatitis B virus. Computed tomography revealed a ring-like enhanced mass 35 mm in diameter at segment 7 in the early phase. The enhancement was prolonged to the late phase through the portal phase, while the shape was irregular. Ethoxybenzy magnetic resonance imaging revealed that the tumor had a low signal intensity on T1-weighted imaging and a high signal intensity on T2-weighted imaging. Diffusion-weighted images identified that the tumor had remarkably high signal intensity. Tumor enhancement was not detected throughout the tumor in the hepatocyte phase. Upon ICC diagnosis, a laparoscopic S7 subsegmentectomy was performed. The patient’s postoperative course was uneventful. An immunohistochemical examination revealed that the cells tested positive for cytokeratin 7 (CK7), CK19, and CD56 and negative for CK20, CD10, α-fetoprotein, thyroid transcription factor-1. At 2 years after surgery, the patient remains alive without recurrence. Conclusions Here we presented a case of clear cell ICC that was treated by laparoscopic hepatectomy. Immunological analysis, especially by CD56 and several CK markers, is helpful for diagnosing this disease.http://link.springer.com/article/10.1186/s40792-020-01041-2Clear cell typeIntrahepatic cholangiocarcinomaLaparoscopic hepatectomy |
| spellingShingle | Takuya Yamamoto Tomoyuki Abe Akihiko Oshita Shuji Yonehara Yoshio Katamura Nozomu Matsumoto Tsuyoshi Kobayashi Masahiro Nakahara Hideki Ohdan Toshio Noriyuki Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery Surgical Case Reports Clear cell type Intrahepatic cholangiocarcinoma Laparoscopic hepatectomy |
| title | Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| title_full | Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| title_fullStr | Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| title_full_unstemmed | Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| title_short | Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| title_sort | intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery |
| topic | Clear cell type Intrahepatic cholangiocarcinoma Laparoscopic hepatectomy |
| url | http://link.springer.com/article/10.1186/s40792-020-01041-2 |
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