The Roles of Deubiquitination in Age-related Diseases
Deubiquitination, mediated by deubiquitinating enzymes (DUBs), represents a crucial class of post-translational protein modifications. Its primary mechanism involves in the interaction of DUBs with ubiquitinated target proteins, whereby the DUBs cleave or remove ubiquitin chains from these targets,...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese General Practice Publishing House Co., Ltd
2025-03-01
|
| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/2024-070708.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849716506700546048 |
|---|---|
| author | XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin |
| author_facet | XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin |
| author_sort | XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin |
| collection | DOAJ |
| description | Deubiquitination, mediated by deubiquitinating enzymes (DUBs), represents a crucial class of post-translational protein modifications. Its primary mechanism involves in the interaction of DUBs with ubiquitinated target proteins, whereby the DUBs cleave or remove ubiquitin chains from these targets, subsequently restoring their expression levels and functional activities. This article systematically reviews the latest research progress on deubiquitination in age-related diseases, covering the types of DUBs, their roles in cellular aging, and the regulatory mechanisms in age-related diseases through different pathways. It also summarizes the research progress in the development of small-molecule drugs targeting DUBs and related mechanisms. This review demonstrates that as the body ages, factors such as decreased protein renewal function and oxidative damage lead to the accumulation of ubiquitinated proteins, resulting in cellular dysfunction. DUBs play an important and complex regulatory role in age-related diseases by modulating mechanisms such as protein homeostasis, mitochondrial function, and cell cycle in aging cells. |
| format | Article |
| id | doaj-art-b85d3c86a7fe4fc39f0502cc72ba6ddb |
| institution | DOAJ |
| issn | 1007-9572 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj-art-b85d3c86a7fe4fc39f0502cc72ba6ddb2025-08-20T03:12:58ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722025-03-0128091143115510.12114/j.issn.1007-9572.2024.0357The Roles of Deubiquitination in Age-related DiseasesXU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin01. Nantong University, Nantong 226001, China;2. Eye Institute, Affiliated Hospital of Nantong University, Nantong 226001, ChinaDeubiquitination, mediated by deubiquitinating enzymes (DUBs), represents a crucial class of post-translational protein modifications. Its primary mechanism involves in the interaction of DUBs with ubiquitinated target proteins, whereby the DUBs cleave or remove ubiquitin chains from these targets, subsequently restoring their expression levels and functional activities. This article systematically reviews the latest research progress on deubiquitination in age-related diseases, covering the types of DUBs, their roles in cellular aging, and the regulatory mechanisms in age-related diseases through different pathways. It also summarizes the research progress in the development of small-molecule drugs targeting DUBs and related mechanisms. This review demonstrates that as the body ages, factors such as decreased protein renewal function and oxidative damage lead to the accumulation of ubiquitinated proteins, resulting in cellular dysfunction. DUBs play an important and complex regulatory role in age-related diseases by modulating mechanisms such as protein homeostasis, mitochondrial function, and cell cycle in aging cells.https://www.chinagp.net/fileup/1007-9572/PDF/2024-070708.pdfaging|age-related diseases|deubiquitination|deubiquitinating enzymes|protein quality control|mitochondrial function |
| spellingShingle | XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin The Roles of Deubiquitination in Age-related Diseases Zhongguo quanke yixue aging|age-related diseases|deubiquitination|deubiquitinating enzymes|protein quality control|mitochondrial function |
| title | The Roles of Deubiquitination in Age-related Diseases |
| title_full | The Roles of Deubiquitination in Age-related Diseases |
| title_fullStr | The Roles of Deubiquitination in Age-related Diseases |
| title_full_unstemmed | The Roles of Deubiquitination in Age-related Diseases |
| title_short | The Roles of Deubiquitination in Age-related Diseases |
| title_sort | roles of deubiquitination in age related diseases |
| topic | aging|age-related diseases|deubiquitination|deubiquitinating enzymes|protein quality control|mitochondrial function |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/2024-070708.pdf |
| work_keys_str_mv | AT xulinhuilipengfeiwumiaomiaokanglihuajiminyuyingguanhuaijin therolesofdeubiquitinationinagerelateddiseases AT xulinhuilipengfeiwumiaomiaokanglihuajiminyuyingguanhuaijin rolesofdeubiquitinationinagerelateddiseases |