Elucidating the function of clusterin in the progression of diabetic kidney disease
Diabetic kidney disease (DKD) is a common microvascular complication and the main cause of death in diabetic patients. Metabolic disorders can accelerate the occurrence and development of DKD through a variety of ways, Recent studies have found that Clusterin (Clu) levels are associated with renal d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1573654/full |
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| author | Lin Mao Ruili Yin Longyan Yang Dong Zhao |
| author_facet | Lin Mao Ruili Yin Longyan Yang Dong Zhao |
| author_sort | Lin Mao |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is a common microvascular complication and the main cause of death in diabetic patients. Metabolic disorders can accelerate the occurrence and development of DKD through a variety of ways, Recent studies have found that Clusterin (Clu) levels are associated with renal dysfunction and can be used as a biomarker of renal tubular injury, while preclinical studies reveal its renoprotective function. This article reviews the molecular mechanisms of Clu in the interaction between various cells in DKD. In addition, we discuss the latest research progress of Clu in the field of DKD. This review aims to explore Clu as a potential therapeutic target for DKD and provide some guidance for future clinical treatment. |
| format | Article |
| id | doaj-art-b85d0709c2a34dc1b929f7677c086baa |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b85d0709c2a34dc1b929f7677c086baa2025-08-20T02:31:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15736541573654Elucidating the function of clusterin in the progression of diabetic kidney diseaseLin MaoRuili YinLongyan YangDong ZhaoDiabetic kidney disease (DKD) is a common microvascular complication and the main cause of death in diabetic patients. Metabolic disorders can accelerate the occurrence and development of DKD through a variety of ways, Recent studies have found that Clusterin (Clu) levels are associated with renal dysfunction and can be used as a biomarker of renal tubular injury, while preclinical studies reveal its renoprotective function. This article reviews the molecular mechanisms of Clu in the interaction between various cells in DKD. In addition, we discuss the latest research progress of Clu in the field of DKD. This review aims to explore Clu as a potential therapeutic target for DKD and provide some guidance for future clinical treatment.https://www.frontiersin.org/articles/10.3389/fphar.2025.1573654/fulldiabetic kidney diseaseclusteringlucose metabolismlipid metabolismoxidative stress |
| spellingShingle | Lin Mao Ruili Yin Longyan Yang Dong Zhao Elucidating the function of clusterin in the progression of diabetic kidney disease Frontiers in Pharmacology diabetic kidney disease clusterin glucose metabolism lipid metabolism oxidative stress |
| title | Elucidating the function of clusterin in the progression of diabetic kidney disease |
| title_full | Elucidating the function of clusterin in the progression of diabetic kidney disease |
| title_fullStr | Elucidating the function of clusterin in the progression of diabetic kidney disease |
| title_full_unstemmed | Elucidating the function of clusterin in the progression of diabetic kidney disease |
| title_short | Elucidating the function of clusterin in the progression of diabetic kidney disease |
| title_sort | elucidating the function of clusterin in the progression of diabetic kidney disease |
| topic | diabetic kidney disease clusterin glucose metabolism lipid metabolism oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1573654/full |
| work_keys_str_mv | AT linmao elucidatingthefunctionofclusterinintheprogressionofdiabetickidneydisease AT ruiliyin elucidatingthefunctionofclusterinintheprogressionofdiabetickidneydisease AT longyanyang elucidatingthefunctionofclusterinintheprogressionofdiabetickidneydisease AT dongzhao elucidatingthefunctionofclusterinintheprogressionofdiabetickidneydisease |