Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome
Purpose of the study. To increase of recurrent bronchitis (RB) immunoprophylaxis effectiveness inchildrenaged 7 to 12 yearswiththevertebrobasilar arterial system syndrome (VBASS). Materials and methods. 60 children aged 7 to 12 years with RB and VBASS were examined. Two groups were formed (30 chi...
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Zaporizhzhia State Medical and Pharmaceutical University
2020-12-01
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| Series: | Сучасні медичні технології |
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| Online Access: | https://zmapo-journal.com/index.php/journal/article/view/106 |
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| author | L. S. Ovcharenko Т. V. Slutskaya A. A. Vertehel T. G. Andrienko I. V. Samokhin A. V. Kryazhev |
| author_facet | L. S. Ovcharenko Т. V. Slutskaya A. A. Vertehel T. G. Andrienko I. V. Samokhin A. V. Kryazhev |
| author_sort | L. S. Ovcharenko |
| collection | DOAJ |
| description | Purpose of the study. To increase of recurrent bronchitis (RB) immunoprophylaxis effectiveness inchildrenaged 7 to 12 yearswiththevertebrobasilar arterial system syndrome (VBASS).
Materials and methods. 60 children aged 7 to 12 years with RB and VBASS were examined. Two groups were formed (30 children each): 1) children with RB and VBASS receiving ω-3 polyunsaturated fatty acids (PUFA) at 300 mg per day during meals for 60 days; 2) children with RB and VBASS receiving multivitamins in a prophylactic daily dose during meals for 60 days. The state of immunity was assessed by data on phagocytosis, CD3, CD4, CD8, CD16, CD19, CD25, CD95; serum levels of IgA, IgG, IgM, tumor necrosis factor-α (TNF-α) and secretory sIgA in saliva.
Results. When ω-3 PUFA is used, the frequency of registration of low indices of phagocytic index decreases (by 16,7%, p < 0,05), phagocytic number (by 28,4%, p < 0,05), index of phagocytosis completion (by 15,0%, p < 0,05), the spontaneous NST-test index (by 10,0%, p < 0,05), the CD16 content (by 10,0%, p < 0,05); the number of children decreases with an increase in CD3 (by 21,7%, p < 0,05), CD8 (by 15,0%, p < 0,05), CD19 (by 16,7%, p < 0,05), CD25 (by 31,6%, p < 0,05), CD95 (by 18,4%, p < 0,05), serum IgG (by 11,7%, p < 0,05), IgM (by 31,7%, p < 0,05), TNF-α (by 30,0%, p < 0,05) and decreased IgA level (by 15,0%, p<0,05), saliva sIgA (by 31,6%, p < 0,05).
Conclusions. The use of ω-3 PUFA is an effective remedy for RB immunoprophylaxis in children with (на 11,7%, р < 0,05), IgМ (на 31,7%, р < 0,05), ФНО-α (на 30,0%, р < 0,05) и сниженного уровня IgА (на 15,0%, р < 0,05), sIgA слюны (на 31,6%, р < 0,05).
VBASS, which is associated with the universal regulatory mechanism of immunotropic influence – protective and anti-inflammatory. |
| format | Article |
| id | doaj-art-b85cb55f86eb49c181d2ac4cb8c0afd5 |
| institution | DOAJ |
| issn | 2072-9367 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
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| series | Сучасні медичні технології |
| spelling | doaj-art-b85cb55f86eb49c181d2ac4cb8c0afd52025-08-20T02:58:45ZengZaporizhzhia State Medical and Pharmaceutical UniversityСучасні медичні технології2072-93672020-12-014(47)525710.34287/MMT.4(47).2020.9106Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndromeL. S. Ovcharenko0Т. V. Slutskaya1A. A. Vertehel2T. G. Andrienko3I. V. Samokhin4A. V. Kryazhev5State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"State institution "Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine"Purpose of the study. To increase of recurrent bronchitis (RB) immunoprophylaxis effectiveness inchildrenaged 7 to 12 yearswiththevertebrobasilar arterial system syndrome (VBASS). Materials and methods. 60 children aged 7 to 12 years with RB and VBASS were examined. Two groups were formed (30 children each): 1) children with RB and VBASS receiving ω-3 polyunsaturated fatty acids (PUFA) at 300 mg per day during meals for 60 days; 2) children with RB and VBASS receiving multivitamins in a prophylactic daily dose during meals for 60 days. The state of immunity was assessed by data on phagocytosis, CD3, CD4, CD8, CD16, CD19, CD25, CD95; serum levels of IgA, IgG, IgM, tumor necrosis factor-α (TNF-α) and secretory sIgA in saliva. Results. When ω-3 PUFA is used, the frequency of registration of low indices of phagocytic index decreases (by 16,7%, p < 0,05), phagocytic number (by 28,4%, p < 0,05), index of phagocytosis completion (by 15,0%, p < 0,05), the spontaneous NST-test index (by 10,0%, p < 0,05), the CD16 content (by 10,0%, p < 0,05); the number of children decreases with an increase in CD3 (by 21,7%, p < 0,05), CD8 (by 15,0%, p < 0,05), CD19 (by 16,7%, p < 0,05), CD25 (by 31,6%, p < 0,05), CD95 (by 18,4%, p < 0,05), serum IgG (by 11,7%, p < 0,05), IgM (by 31,7%, p < 0,05), TNF-α (by 30,0%, p < 0,05) and decreased IgA level (by 15,0%, p<0,05), saliva sIgA (by 31,6%, p < 0,05). Conclusions. The use of ω-3 PUFA is an effective remedy for RB immunoprophylaxis in children with (на 11,7%, р < 0,05), IgМ (на 31,7%, р < 0,05), ФНО-α (на 30,0%, р < 0,05) и сниженного уровня IgА (на 15,0%, р < 0,05), sIgA слюны (на 31,6%, р < 0,05). VBASS, which is associated with the universal regulatory mechanism of immunotropic influence – protective and anti-inflammatory.https://zmapo-journal.com/index.php/journal/article/view/106childrenpolyunsaturated fatty acidsimmunityprevention |
| spellingShingle | L. S. Ovcharenko Т. V. Slutskaya A. A. Vertehel T. G. Andrienko I. V. Samokhin A. V. Kryazhev Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome Сучасні медичні технології children polyunsaturated fatty acids immunity prevention |
| title | Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| title_full | Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| title_fullStr | Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| title_full_unstemmed | Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| title_short | Recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| title_sort | recurrent bronchitis immunomodulation in children with vertebrobasilar arterial system syndrome |
| topic | children polyunsaturated fatty acids immunity prevention |
| url | https://zmapo-journal.com/index.php/journal/article/view/106 |
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