Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH
A green one-pot synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives which are the main core of the natural product of Polyneomarline C is described by the reaction of 4-chloro-3-formyl coumarin and different cyclic and acyclic compounds having active methylene group in presence of Et3N and NH4O...
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| Format: | Article |
| Language: | English |
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Ural Federal University
2022-06-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/5874 |
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| author | Shrishnu Kumar Kundu Susanta Patra Chayan Sardar Sunil Kumar Bhanja Prasanta Patra |
| author_facet | Shrishnu Kumar Kundu Susanta Patra Chayan Sardar Sunil Kumar Bhanja Prasanta Patra |
| author_sort | Shrishnu Kumar Kundu |
| collection | DOAJ |
| description | A green one-pot synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives which are the main core of the natural product of Polyneomarline C is described by the reaction of 4-chloro-3-formyl coumarin and different cyclic and acyclic compounds having active methylene group in presence of Et3N and NH4OAc in EtOH. The advantages of this strategy are good yields, no need for the chromatographic separation and the absence of heavy metal catalysts and toxic by-products. The 4-chloro-3-formyl coumarin is obtained by Vilsmeier Heck reaction of 4-hydroxy coumarin. |
| format | Article |
| id | doaj-art-b858871efb374fc1a44b4cc1a20127d4 |
| institution | OA Journals |
| issn | 2411-1414 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Ural Federal University |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-b858871efb374fc1a44b4cc1a20127d42025-08-20T02:19:07ZengUral Federal UniversityChimica Techno Acta2411-14142022-06-019210.15826/chimtech.2022.9.2.114450Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOHShrishnu Kumar Kundu0Susanta Patra1Chayan Sardar2Sunil Kumar Bhanja3Prasanta Patra4Acharya Prafulla Chandra Roy Government CollegeJhargram Raj CollegeTechno-India UniversityGovernment General Degree CollegeJhargram Raj CollegeA green one-pot synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives which are the main core of the natural product of Polyneomarline C is described by the reaction of 4-chloro-3-formyl coumarin and different cyclic and acyclic compounds having active methylene group in presence of Et3N and NH4OAc in EtOH. The advantages of this strategy are good yields, no need for the chromatographic separation and the absence of heavy metal catalysts and toxic by-products. The 4-chloro-3-formyl coumarin is obtained by Vilsmeier Heck reaction of 4-hydroxy coumarin.https://chimicatechnoacta.ru/article/view/58745h-chromeno[4,3-b]pyridin-5-onegreen synthesis4-chloro-3-formyl coumarinactive methylene grouppolyalthia nemoralis c |
| spellingShingle | Shrishnu Kumar Kundu Susanta Patra Chayan Sardar Sunil Kumar Bhanja Prasanta Patra Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH Chimica Techno Acta 5h-chromeno[4,3-b]pyridin-5-one green synthesis 4-chloro-3-formyl coumarin active methylene group polyalthia nemoralis c |
| title | Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH |
| title_full | Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH |
| title_fullStr | Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH |
| title_full_unstemmed | Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH |
| title_short | Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH |
| title_sort | synthesis of 5h chromeno 4 3 b pyridin 5 one derivatives as a backbone of natural product polyneomarline c scaffolds in presence of et3n and nh4oac in etoh |
| topic | 5h-chromeno[4,3-b]pyridin-5-one green synthesis 4-chloro-3-formyl coumarin active methylene group polyalthia nemoralis c |
| url | https://chimicatechnoacta.ru/article/view/5874 |
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