Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis
Abstract Rotavirus (RV) is a leading cause of severe diarrhea among children under five years of age in China. In this meta-analysis, we assessed the disease burden of RV-related diarrhea by analyzing 73 studies retrieved from the PubMed, Web of Science, China National Knowledge Infrastructure, and...
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| Format: | Article |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-00778-w |
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| author | Li Cai Bicheng Tang Fanxu Kong Zhaorui Chang Yanping Zhang Yaming Zheng Liping Wang |
| author_facet | Li Cai Bicheng Tang Fanxu Kong Zhaorui Chang Yanping Zhang Yaming Zheng Liping Wang |
| author_sort | Li Cai |
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| description | Abstract Rotavirus (RV) is a leading cause of severe diarrhea among children under five years of age in China. In this meta-analysis, we assessed the disease burden of RV-related diarrhea by analyzing 73 studies retrieved from the PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases (2013–2023). The incidence of RV-related diarrhea ranged from 0.637 /1000 to 31.46/1000 persons. The pooled RV positivity rate for the under-5 age group was 24.7% (95% confidence interval: 22.1–27.4), with higher positivity rates observed among inpatients compared to outpatients (24.1% vs. 22.2%). Notably, the RV positivity rate declined from 27.3 to 21.5% pre- and post- the RotaTeq® licensure and 28.8–22.5% following the COVID-19 pandemic. The G9P[8] genotype was predominant, accounting for 71.7% of the RV cases in the under-5 age group. Given the dynamic nature of the incidence rate of RV-related diarrhea and the prevalence of the G9P[8] genotype, it is imperative to enhance surveillance efforts targeting incidence of RV-related diarrhea and the circulating genotypes of rotavirus. |
| format | Article |
| id | doaj-art-b8585a9c77324c679e4bb489eacd367a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b8585a9c77324c679e4bb489eacd367a2025-08-20T02:15:11ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-00778-wDisease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysisLi Cai0Bicheng Tang1Fanxu Kong2Zhaorui Chang3Yanping Zhang4Yaming Zheng5Liping Wang6Division of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionThe Sixth People’s Hospital of DongguanDivision of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionDivision of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionDivision of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionDivision of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionDivision of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and PreventionAbstract Rotavirus (RV) is a leading cause of severe diarrhea among children under five years of age in China. In this meta-analysis, we assessed the disease burden of RV-related diarrhea by analyzing 73 studies retrieved from the PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases (2013–2023). The incidence of RV-related diarrhea ranged from 0.637 /1000 to 31.46/1000 persons. The pooled RV positivity rate for the under-5 age group was 24.7% (95% confidence interval: 22.1–27.4), with higher positivity rates observed among inpatients compared to outpatients (24.1% vs. 22.2%). Notably, the RV positivity rate declined from 27.3 to 21.5% pre- and post- the RotaTeq® licensure and 28.8–22.5% following the COVID-19 pandemic. The G9P[8] genotype was predominant, accounting for 71.7% of the RV cases in the under-5 age group. Given the dynamic nature of the incidence rate of RV-related diarrhea and the prevalence of the G9P[8] genotype, it is imperative to enhance surveillance efforts targeting incidence of RV-related diarrhea and the circulating genotypes of rotavirus.https://doi.org/10.1038/s41598-025-00778-w |
| spellingShingle | Li Cai Bicheng Tang Fanxu Kong Zhaorui Chang Yanping Zhang Yaming Zheng Liping Wang Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis Scientific Reports |
| title | Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis |
| title_full | Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis |
| title_fullStr | Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis |
| title_full_unstemmed | Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis |
| title_short | Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis |
| title_sort | disease burden of rotavirus related diarrhea in children under 5 years in china a meta analysis |
| url | https://doi.org/10.1038/s41598-025-00778-w |
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