Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study
Abstract Background Cerebral small vessel disease (CSVD) causes significant disability at increasing age, such as cognitive impairment, gait, and sphincteric problems affecting a person’s quality of life. That is why it is essential to be detected and managed early. The aim of this study is to inves...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-025-01001-3 |
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| author | Yasmine Hassan Abdelhamid Eman Hamid Mena Elerian Hossam Shokri Mai Fathy Tamer Roushdy Hani Zakieldine Nevine El Nahas Hany Aref |
| author_facet | Yasmine Hassan Abdelhamid Eman Hamid Mena Elerian Hossam Shokri Mai Fathy Tamer Roushdy Hani Zakieldine Nevine El Nahas Hany Aref |
| author_sort | Yasmine Hassan Abdelhamid |
| collection | DOAJ |
| description | Abstract Background Cerebral small vessel disease (CSVD) causes significant disability at increasing age, such as cognitive impairment, gait, and sphincteric problems affecting a person’s quality of life. That is why it is essential to be detected and managed early. The aim of this study is to investigate clinical and radiological progression among a sample of Egyptian patients with incidental CSVD after a 1-year antiplatelet therapy, either aspirin or cilostazol. Results Regarding the MRI lesions, both visual rating scales and lesion load assessment did not show any significant difference between baseline and follow-up. As for the clinical assessment, there was also no significant difference between the two groups at baseline and follow-up. Conclusion Neither aspirin nor cilostazol had an impact on clinical and radiological progression over 1 year in patients with CSVD. More sophisticated tools are needed to assess radiological progression in CSVD. The trial is registered in PACTR No. PACTR202301861240705. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=19331 . Date of Approval: 31/1/2023. |
| format | Article |
| id | doaj-art-b857bf9b61854c76b186fdfac72d0ce6 |
| institution | DOAJ |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-b857bf9b61854c76b186fdfac72d0ce62025-08-20T03:04:26ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-07-0161111010.1186/s41983-025-01001-3Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot studyYasmine Hassan Abdelhamid0Eman Hamid1Mena Elerian2Hossam Shokri3Mai Fathy4Tamer Roushdy5Hani Zakieldine6Nevine El Nahas7Hany Aref8Ain Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAbstract Background Cerebral small vessel disease (CSVD) causes significant disability at increasing age, such as cognitive impairment, gait, and sphincteric problems affecting a person’s quality of life. That is why it is essential to be detected and managed early. The aim of this study is to investigate clinical and radiological progression among a sample of Egyptian patients with incidental CSVD after a 1-year antiplatelet therapy, either aspirin or cilostazol. Results Regarding the MRI lesions, both visual rating scales and lesion load assessment did not show any significant difference between baseline and follow-up. As for the clinical assessment, there was also no significant difference between the two groups at baseline and follow-up. Conclusion Neither aspirin nor cilostazol had an impact on clinical and radiological progression over 1 year in patients with CSVD. More sophisticated tools are needed to assess radiological progression in CSVD. The trial is registered in PACTR No. PACTR202301861240705. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=19331 . Date of Approval: 31/1/2023.https://doi.org/10.1186/s41983-025-01001-3Cerebral small vessel diseaseAspirinCilostazolOutcomeMRI |
| spellingShingle | Yasmine Hassan Abdelhamid Eman Hamid Mena Elerian Hossam Shokri Mai Fathy Tamer Roushdy Hani Zakieldine Nevine El Nahas Hany Aref Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Cerebral small vessel disease Aspirin Cilostazol Outcome MRI |
| title | Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study |
| title_full | Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study |
| title_fullStr | Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study |
| title_full_unstemmed | Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study |
| title_short | Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study |
| title_sort | clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy randomized pilot study |
| topic | Cerebral small vessel disease Aspirin Cilostazol Outcome MRI |
| url | https://doi.org/10.1186/s41983-025-01001-3 |
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