Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates
As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the ra...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2018/8493439 |
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| author | Vukoman Jokanović Božana Čolović Bogomir Bolka Prokić Nada Tomanović Marijana Popović Bajić Slavoljub Živković |
| author_facet | Vukoman Jokanović Božana Čolović Bogomir Bolka Prokić Nada Tomanović Marijana Popović Bajić Slavoljub Živković |
| author_sort | Vukoman Jokanović |
| collection | DOAJ |
| description | As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment. |
| format | Article |
| id | doaj-art-b8562a52e8bf4c8faed7440a86539f1b |
| institution | DOAJ |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-b8562a52e8bf4c8faed7440a86539f1b2025-08-20T03:22:46ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422018-01-01201810.1155/2018/84934398493439Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium SilicatesVukoman Jokanović0Božana Čolović1Bogomir Bolka Prokić2Nada Tomanović3Marijana Popović Bajić4Slavoljub Živković5Vinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, 11001 Belgrade, SerbiaVinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, 11001 Belgrade, SerbiaSchool of Veterinary Medicine, University of Belgrade, Bulevar Oslobodjenja 19, 11000 Belgrade, SerbiaInstitute of Pathology, School of Medicine, University of Belgrade, Doktora Subotića Starijeg 1, 11000 Belgrade, SerbiaDepartment of Restorative Dentistry and Endodontics, School of Dental Medicine, University of Belgrade, Rankeova 4, 11000 Belgrade, SerbiaDepartment of Restorative Dentistry and Endodontics, School of Dental Medicine, University of Belgrade, Rankeova 4, 11000 Belgrade, SerbiaAs an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.http://dx.doi.org/10.1155/2018/8493439 |
| spellingShingle | Vukoman Jokanović Božana Čolović Bogomir Bolka Prokić Nada Tomanović Marijana Popović Bajić Slavoljub Živković Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates Advances in Materials Science and Engineering |
| title | Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates |
| title_full | Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates |
| title_fullStr | Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates |
| title_full_unstemmed | Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates |
| title_short | Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates |
| title_sort | subchronic systemic toxicity of new endodontic material based on calcium hydroxyapatite and calcium silicates |
| url | http://dx.doi.org/10.1155/2018/8493439 |
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