The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial
Background: Laparoscopic cholecystectomy is associated with postoperative pain in the upper and lower abdomen, back, and shoulder region which persist for 2–3 days. Vitamin C is a powerful reductant with antioxidant, neuroprotective, and neuromodulation effects. It is successfully used in complex re...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pain |
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| Online Access: | https://journals.lww.com/10.4103/ijpn.ijpn_87_24 |
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| author | Renu Bala Ram Murti Saini Shashi Kiran Priyanka Bansal Kirti Kshetrapal Pulkita Kataria |
| author_facet | Renu Bala Ram Murti Saini Shashi Kiran Priyanka Bansal Kirti Kshetrapal Pulkita Kataria |
| author_sort | Renu Bala |
| collection | DOAJ |
| description | Background:
Laparoscopic cholecystectomy is associated with postoperative pain in the upper and lower abdomen, back, and shoulder region which persist for 2–3 days. Vitamin C is a powerful reductant with antioxidant, neuroprotective, and neuromodulation effects. It is successfully used in complex regional pain syndrome and few surgeries. In the present study, its effect on postoperative pain after laparoscopic cholecystectomy has been assessed.
Materials and Methods:
The present, prospective, randomized double-blind study was conducted following approval from the institutional ethics committee. Sixty adult patients either sex, the American Society of Anesthesiologists I or II were randomized to group C who received 1 g Vitamin C intraoperatively, whereas Group N received normal saline (control group). Standardized anesthesia protocol was followed in all patients. Postoperative pain was assessed as per the numeric rating scale. For rescue analgesia acetaminophen, ketorolac and diclofenac were given. Follow-up period was 24 h after surgery.
Results:
The demographic profile was comparable into two groups. Postoperative pain scores were lower in Group C as compared to Group N. There was reduced demand for rescue analgesic in Group C. None of the patients reported any adverse event.
Conclusion:
A single dose of 1 g Vitamin C intraoperatively helped in obtunding pain following laparoscopic cholecystectomy with no side effects. Hence, it may be incorporated as a component of multimodal analgesic regimen. |
| format | Article |
| id | doaj-art-b853c244cd6f41409c639f00cdac3c4f |
| institution | Kabale University |
| issn | 0970-5333 2321-7820 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj-art-b853c244cd6f41409c639f00cdac3c4f2025-01-07T06:39:48ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332321-78202024-12-0138319019410.4103/ijpn.ijpn_87_24The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind TrialRenu BalaRam Murti SainiShashi KiranPriyanka BansalKirti KshetrapalPulkita KatariaBackground: Laparoscopic cholecystectomy is associated with postoperative pain in the upper and lower abdomen, back, and shoulder region which persist for 2–3 days. Vitamin C is a powerful reductant with antioxidant, neuroprotective, and neuromodulation effects. It is successfully used in complex regional pain syndrome and few surgeries. In the present study, its effect on postoperative pain after laparoscopic cholecystectomy has been assessed. Materials and Methods: The present, prospective, randomized double-blind study was conducted following approval from the institutional ethics committee. Sixty adult patients either sex, the American Society of Anesthesiologists I or II were randomized to group C who received 1 g Vitamin C intraoperatively, whereas Group N received normal saline (control group). Standardized anesthesia protocol was followed in all patients. Postoperative pain was assessed as per the numeric rating scale. For rescue analgesia acetaminophen, ketorolac and diclofenac were given. Follow-up period was 24 h after surgery. Results: The demographic profile was comparable into two groups. Postoperative pain scores were lower in Group C as compared to Group N. There was reduced demand for rescue analgesic in Group C. None of the patients reported any adverse event. Conclusion: A single dose of 1 g Vitamin C intraoperatively helped in obtunding pain following laparoscopic cholecystectomy with no side effects. Hence, it may be incorporated as a component of multimodal analgesic regimen.https://journals.lww.com/10.4103/ijpn.ijpn_87_24cholecystectomylaparoscopypainpostoperativevitamin c |
| spellingShingle | Renu Bala Ram Murti Saini Shashi Kiran Priyanka Bansal Kirti Kshetrapal Pulkita Kataria The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial Indian Journal of Pain cholecystectomy laparoscopy pain postoperative vitamin c |
| title | The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial |
| title_full | The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial |
| title_fullStr | The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial |
| title_full_unstemmed | The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial |
| title_short | The Effectiveness of Vitamin C for Postoperative Pain Relief in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Double-blind Trial |
| title_sort | effectiveness of vitamin c for postoperative pain relief in patients undergoing laparoscopic cholecystectomy a prospective randomized double blind trial |
| topic | cholecystectomy laparoscopy pain postoperative vitamin c |
| url | https://journals.lww.com/10.4103/ijpn.ijpn_87_24 |
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