The effect of prolonged G-quadruplex stabilization on the functions of human cells

The effect of prolonged G-quadruplex stabilization on the functions of human cells

Abstract Guanine-rich DNA sequences have a propensity to form G-quadruplex structures. These structures play several important biological roles and are potential targets for anticancer drugs. However, no G-quadruplex-stabilizing agent has yet been approved for clinical use. Given that G-quadruplex s...

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Bibliographic Details
Main Authors: Nargis Karatayeva, Lili Hegedus, Arindam Bhattacharjee, Eszter Nemeth, Adam Poti, Lorinc Pongor, Gabor Juhasz, David Szuts, Peter Burkovics
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
G-quadruplex
PhenDC3
Genome stability
Mitophagy
Online Access:https://doi.org/10.1038/s41598-025-04791-x
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