PtWAVE: a high-sensitive deconvolution software of sequencing trace for the detection of large indels in genome editing

Abstract Background Tracking of Insertions and DEletions (TIDE) analysis, which computationally deconvolves capillary sequencing data derived from the DNA of bulk or clonal cell populations to estimate the efficiency of targeted mutagenesis by programmable nucleases, has played a significant role in...

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Bibliographic Details
Main Authors: Kazuki Nakamae, Saya Ide, Nagaki Ohnuki, Yoshiko Nakagawa, Keisuke Okuhara, Hidemasa Bono
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Bioinformatics
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Online Access:https://doi.org/10.1186/s12859-025-06139-8
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