MCMs in Cancer: Prognostic Potential and Mechanisms
Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells. Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle. Overexpressed MCMs are detected in var...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/3750294 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849686203514748928 |
|---|---|
| author | Si Yu Guanqun Wang Yue Shi Haifeng Xu Yongchang Zheng Yang Chen |
| author_facet | Si Yu Guanqun Wang Yue Shi Haifeng Xu Yongchang Zheng Yang Chen |
| author_sort | Si Yu |
| collection | DOAJ |
| description | Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells. Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle. Overexpressed MCMs are detected in various cancerous tissues and cancer cell lines. Previous studies have proposed MCMs as promising proliferation markers in cancers, while the prognostic values remain controversial and the underlying mechanisms remain unascertained. This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed. This work also offers insight into the mechanisms of MCMs prompting carcinogenesis and adverse prognosis, providing information for future research. Finally, MCMs in liver cancer are specifically discussed, and future perspectives are provided. |
| format | Article |
| id | doaj-art-b83f2d41a4d247a091b3fb98c9dffe7a |
| institution | DOAJ |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-b83f2d41a4d247a091b3fb98c9dffe7a2025-08-20T03:22:48ZengWileyAnalytical Cellular Pathology2210-71772210-71852020-01-01202010.1155/2020/37502943750294MCMs in Cancer: Prognostic Potential and MechanismsSi Yu0Guanqun Wang1Yue Shi2Haifeng Xu3Yongchang Zheng4Yang Chen5Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaSchool of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, Center for Synthetic and Systems Biology, Ministry of Education Key Laboratory of Bioinformatics, Tsinghua University, Beijing 100084, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaMOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing 100084, ChinaEnabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells. Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle. Overexpressed MCMs are detected in various cancerous tissues and cancer cell lines. Previous studies have proposed MCMs as promising proliferation markers in cancers, while the prognostic values remain controversial and the underlying mechanisms remain unascertained. This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed. This work also offers insight into the mechanisms of MCMs prompting carcinogenesis and adverse prognosis, providing information for future research. Finally, MCMs in liver cancer are specifically discussed, and future perspectives are provided.http://dx.doi.org/10.1155/2020/3750294 |
| spellingShingle | Si Yu Guanqun Wang Yue Shi Haifeng Xu Yongchang Zheng Yang Chen MCMs in Cancer: Prognostic Potential and Mechanisms Analytical Cellular Pathology |
| title | MCMs in Cancer: Prognostic Potential and Mechanisms |
| title_full | MCMs in Cancer: Prognostic Potential and Mechanisms |
| title_fullStr | MCMs in Cancer: Prognostic Potential and Mechanisms |
| title_full_unstemmed | MCMs in Cancer: Prognostic Potential and Mechanisms |
| title_short | MCMs in Cancer: Prognostic Potential and Mechanisms |
| title_sort | mcms in cancer prognostic potential and mechanisms |
| url | http://dx.doi.org/10.1155/2020/3750294 |
| work_keys_str_mv | AT siyu mcmsincancerprognosticpotentialandmechanisms AT guanqunwang mcmsincancerprognosticpotentialandmechanisms AT yueshi mcmsincancerprognosticpotentialandmechanisms AT haifengxu mcmsincancerprognosticpotentialandmechanisms AT yongchangzheng mcmsincancerprognosticpotentialandmechanisms AT yangchen mcmsincancerprognosticpotentialandmechanisms |