ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification

ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification

Sicheng Yan,1 Xiaomeng Hu,1 Yan Wu,1 Wangfang Ye,1 Yuehong Zhu,1 Yuxuan He,1 Fuyuan Zhan,1,2 Wei Wu,3 Zhihong Ma1,2 1Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, 313000, People’s Repu...

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Bibliographic Details
Main Authors: Yan S, Hu X, Wu Y, Ye W, Zhu Y, He Y, Zhan F, Wu W, Ma Z
Format: Article
Language:English
Published: Dove Medical Press 2025-05-01
Series:Drug Design, Development and Therapy
Subjects:
5-FU
gastric cancer
network pharmacology
molecular docking
ITGA4
PI3K/AKT pathway
Online Access:https://www.dovepress.com/itga4-contributes-to-5-fluorouracil-resistance-by-up-regulating-pi3kak-peer-reviewed-fulltext-article-DDDT
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