Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy
Chemotherapy-induced nausea and vomiting is a common problem during cancer treatment, especially in breast cancer patients with anthracycline/cyclophosphamide (ас) chemotherapy. Netupitant/palonosetron (NEPA; Akynzeo®) is a fixed-dose combination of two drugs (netupitant, a neurokinin 1 receptor ant...
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ABV-press
2023-10-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1138 |
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| author | A. G. Kedrova A. I. Berishvili |
| author_facet | A. G. Kedrova A. I. Berishvili |
| author_sort | A. G. Kedrova |
| collection | DOAJ |
| description | Chemotherapy-induced nausea and vomiting is a common problem during cancer treatment, especially in breast cancer patients with anthracycline/cyclophosphamide (ас) chemotherapy. Netupitant/palonosetron (NEPA; Akynzeo®) is a fixed-dose combination of two drugs (netupitant, a neurokinin 1 receptor antagonist; and palonosetron, a serotonin 3 receptor antagonist) which target two diferent signalling pathways involved in the induction of vomiting. Approved for use in the prevention of acute and delayed chemotherapy-induced nausea and vomiting in adults, netupitant/palonosetron is given orally or via intravenous infusion as a single dose prior to chemotherapy. In clinical trials, high proportions of patients who received netupitant/palonosetron (used in combination with the corticosteroid dexamethasone) prior to chemotherapy reported no vomiting, no requirement for rescue medication, and no signifcant nausea in the 5 days post chemotherapy. Both the oral and intravenous formulations of the drug combination are well tolerated. Thus, netupitant/palonosetron is a simple, convenient and efective drug combination for the prevention of acute and delayed xhemotherapy-induced nausea and vomiting in patients receiving chemotherapy that has a moderate to high emetogenic potential. |
| format | Article |
| id | doaj-art-b838d9da32ad4bc99406484b1b2a30b6 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-b838d9da32ad4bc99406484b1b2a30b62025-08-20T04:00:08ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272023-10-01193546210.17650/1994-4098-2023-19-3-54-62813Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapyA. G. Kedrova0A. I. Berishvili1Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation; Federal Research and Clinical Center, Federal Biomedical AgencyFederal Research and Clinical Center, Federal Biomedical AgencyChemotherapy-induced nausea and vomiting is a common problem during cancer treatment, especially in breast cancer patients with anthracycline/cyclophosphamide (ас) chemotherapy. Netupitant/palonosetron (NEPA; Akynzeo®) is a fixed-dose combination of two drugs (netupitant, a neurokinin 1 receptor antagonist; and palonosetron, a serotonin 3 receptor antagonist) which target two diferent signalling pathways involved in the induction of vomiting. Approved for use in the prevention of acute and delayed chemotherapy-induced nausea and vomiting in adults, netupitant/palonosetron is given orally or via intravenous infusion as a single dose prior to chemotherapy. In clinical trials, high proportions of patients who received netupitant/palonosetron (used in combination with the corticosteroid dexamethasone) prior to chemotherapy reported no vomiting, no requirement for rescue medication, and no signifcant nausea in the 5 days post chemotherapy. Both the oral and intravenous formulations of the drug combination are well tolerated. Thus, netupitant/palonosetron is a simple, convenient and efective drug combination for the prevention of acute and delayed xhemotherapy-induced nausea and vomiting in patients receiving chemotherapy that has a moderate to high emetogenic potential.https://ojrs.abvpress.ru/ojrs/article/view/1138netupitantpalonosetronnepaakynzeochemotherapybreast cancervomitingnauseaprevention |
| spellingShingle | A. G. Kedrova A. I. Berishvili Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy Опухоли женской репродуктивной системы netupitant palonosetron nepa akynzeo chemotherapy breast cancer vomiting nausea prevention |
| title | Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| title_full | Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| title_fullStr | Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| title_full_unstemmed | Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| title_short | Netupitant/palonosetron (NEPA; Akynzeo®) combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| title_sort | netupitant palonosetron nepa akynzeo r combination in prevention of the nausea and vomiting in patients with breast cancer receiving anthracyclinbased chemotherapy |
| topic | netupitant palonosetron nepa akynzeo chemotherapy breast cancer vomiting nausea prevention |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1138 |
| work_keys_str_mv | AT agkedrova netupitantpalonosetronnepaakynzeocombinationinpreventionofthenauseaandvomitinginpatientswithbreastcancerreceivinganthracyclinbasedchemotherapy AT aiberishvili netupitantpalonosetronnepaakynzeocombinationinpreventionofthenauseaandvomitinginpatientswithbreastcancerreceivinganthracyclinbasedchemotherapy |