Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

Show other versions (1)

Saved in:

Bibliographic Details
Main Authors:	Indi P. Joore, Sawsan Shehata, Irena Muffels, Jose Castro-Alpízar, Elena Jiménez-Curiel, Emilia Nagyova, Natacha Levy, Ziqin Tang, Kimberly Smit, Wilbert P. Vermeij, Richard Rodenburg, Raymond Schiffelers, Edward E.S. Nieuwenhuis, Peter M. van Hasselt, Sabine A. Fuchs, Martijn A. J. Koppens
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-06-01
Series:	PLoS Biology
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186987/?tool=EBI
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors.
by: Indi P Joore, et al.
Published: (2025-06-01)

Imaging flow cytometry reveals divergent mitochondrial phenotypes in mitochondrial disease patients
by: Irena.J.J. Muffels, et al.
Published: (2025-01-01)

Mitochondrial disorders in children: toward development of small‐molecule treatment strategies
by: Werner JH Koopman, et al.
Published: (2016-03-01)

Noninvasive Assessments of Mitochondrial Capacity in People with Mitochondrial Myopathies
by: Kevin K. McCully, et al.
Published: (2024-11-01)

Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia.
by: Avani Solanki, et al.
Published: (2020-01-01)

Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer
by: Yun Wei, et al.
Published: (2024-12-01)

Mitochondrial disorders in neuromuscular pathology
by: S. V. Kotov, et al.
Published: (2019-11-01)

A novel mitochondrial-protective anticonvulsant compound for mitochondrial disease
by: Eddie Hildebrand, et al.
Published: (2025-07-01)

Mitochondrial Transplantation Therapeutics: Assessing Mitochondrial Viability in Extracellular Milieu
by: Eaman Abay, et al.
Published: (2025-06-01)

The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors
by: Yihong Liu, et al.
Published: (2025-02-01)

Mitochondrial function maintenance and mitochondrial training in ageing and related diseases
by: Gan Gao, et al.
Published: (2025-06-01)

Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
by: Michael Aschner, et al.
Published: (2024-12-01)

Mitochondrial DNA Pathogenic Variant Prevalence in Primary Mitochondrial Disease Patients With African (L) Mitochondrial Genome Haplogroups
by: Surita Meldau, et al.
Published: (2025-07-01)

Challenges to understand the mitochondrial respiratory diseases caused by mitochondrial DNA mutations
by: Suely Kazue Nagahashi Marie
Published: (2015-11-01)

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
by: Chunyue Liu, et al.
Published: (2022-06-01)

Mitochondrial dynamics and cancer
by: Paola Maycotte, et al.
Published: (2017-05-01)

Renal Mitochondrial Cytopathies
by: Francesco Emma, et al.
Published: (2011-01-01)

The challenges of mitochondrial replacement.
by: Patrick F Chinnery, et al.
Published: (2014-04-01)

Mapping mitochondrial aging
by: Alessandro Bitto
Published: (2024-12-01)

Mitochondrial RNA maturation
by: Zofia M. Chrzanowska-Lightowlers, et al.
Published: (2024-12-01)

Outcome of Mitochondrial Diseases
by: J Gordon Millichap
Published: (2011-05-01)

Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening
by: Youxiao Ren, et al.
Published: (2025-03-01)

Tissue-specific mitochondrial DNA, MT-TF, pathogenic variants in mitochondrial myopathies
by: Sylvia Rose, et al.
Published: (2025-06-01)

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease
by: Julie Faitg, et al.
Published: (2025-01-01)

Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage
by: Tsutomu Shimura, et al.
Published: (2025-07-01)

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age
by: Dylan C Sarver, et al.
Published: (2024-12-01)

AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
by: HyunJun Kang, et al.
Published: (2024-12-01)

The mitochondrial genomes of Macrotermes termites endemic to Ethiopia
by: P. Conrad Williams, et al.
Published: (2025-06-01)

The role of estrogens in mitochondrial metabolism
by: O. I. Kit, et al.
Published: (2024-07-01)

Silver Nanoparticles and Mitochondrial Interaction
by: Eriberto Bressan, et al.
Published: (2013-01-01)

Mitochondrial Ribosomal Proteins and Cancer
by: Huiyi Wu, et al.
Published: (2025-01-01)

Mitochondrial ataxia - Unravelling the puzzle
by: Neha Pandita, et al.
Published: (2024-05-01)

Mitochondrial disease and epilepsy in children
by: Xuan Zhang, et al.
Published: (2025-01-01)

Formation and Regulation of Mitochondrial Membranes
by: Laila Cigana Schenkel, et al.
Published: (2014-01-01)

Mitochondrial myopathy and myoclonic epilepsy
by: Walter O. Arruda, et al.
Published: (1990-03-01)

Viruses as Modulators of Mitochondrial Functions
by: Sanjeev K. Anand, et al.
Published: (2013-01-01)

Mitochondrial Hypermetabolic Neurons in Epilepsy
by: J Gordon Millichap
Published: (2012-01-01)

Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
by: HyunJun Kang, et al.
Published: (2025-04-01)

Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus
by: Guanfei Zhao, et al.
Published: (2025-06-01)

Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease
by: Lindsey Van Haute, et al.
Published: (2024-11-01)