Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy
Abstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium‐doped Ag/Ag2S Janus nanoparticles (Ag/Ag2SexSy JNPs) is presented as radio‐responsive molecular probes for precise tu...
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202417828 |
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| author | Kang Zhu Zhanyuan Li Jingjing Cao Yixi Cao Jimei Wang Shiyu Wang Ling Chen Huiqin Zhou Wei Huang Hanxun Zou Qunsheng Li Jing Mu Jibin Song |
| author_facet | Kang Zhu Zhanyuan Li Jingjing Cao Yixi Cao Jimei Wang Shiyu Wang Ling Chen Huiqin Zhou Wei Huang Hanxun Zou Qunsheng Li Jing Mu Jibin Song |
| author_sort | Kang Zhu |
| collection | DOAJ |
| description | Abstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium‐doped Ag/Ag2S Janus nanoparticles (Ag/Ag2SexSy JNPs) is presented as radio‐responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X‐ray absorption and energy storage properties. Upon X‐ray irradiation, the Ag/Ag2SexSy JNPs interact with overexpressed hydrogen peroxide (H2O2) in tumor cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce tumor cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency and enhances the photocurrent response, promoting increased electron transfer and ·OH generation, thus amplifying reactive oxygen species (ROS) production and enhancing radiosensitization. Furthermore, the fluorescence “OFF‐ON” mechanism, triggered by H2O2‐induced etching of silver allows real‐time monitoring of H2O2 levels via the second near‐infrared window (NIR‐II) fluorescence (FL) imaging “Turn On”, which delineates tumor boundaries for precise RT and reduce side effects to normal tissue. This dual‐functional platform not only enables real‐time tracking but also enhances therapeutic outcomes, offering a promising approach to precision cancer treatment. |
| format | Article |
| id | doaj-art-b832ba99751b4776a04f5b8cf62b3bb7 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-b832ba99751b4776a04f5b8cf62b3bb72025-08-20T03:22:15ZengWileyAdvanced Science2198-38442025-06-011223n/an/a10.1002/advs.202417828Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization TherapyKang Zhu0Zhanyuan Li1Jingjing Cao2Yixi Cao3Jimei Wang4Shiyu Wang5Ling Chen6Huiqin Zhou7Wei Huang8Hanxun Zou9Qunsheng Li10Jing Mu11Jibin Song12State Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Department of Radiation Oncology Jinan 250117 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaSchool of Materials Science and Engineering University of Jinan Jinan 250022 P. R. ChinaSchool of Materials Science and Engineering University of Jinan Jinan 250022 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Department of Radiation Oncology Jinan 250117 P. R. ChinaFujian Provincial Key Laboratory of Ecology‐Toxicological Effects & Control for Emerging Contaminants Key Laboratory of Ecological Environment and Information Atlas College of Environmental and Biological Engineering Putian University Putian 351100 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaInstitute of Precision Medicine Peking University Shenzhen Hospital Shenzhen 518036 P. R. ChinaState Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. ChinaAbstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium‐doped Ag/Ag2S Janus nanoparticles (Ag/Ag2SexSy JNPs) is presented as radio‐responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X‐ray absorption and energy storage properties. Upon X‐ray irradiation, the Ag/Ag2SexSy JNPs interact with overexpressed hydrogen peroxide (H2O2) in tumor cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce tumor cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency and enhances the photocurrent response, promoting increased electron transfer and ·OH generation, thus amplifying reactive oxygen species (ROS) production and enhancing radiosensitization. Furthermore, the fluorescence “OFF‐ON” mechanism, triggered by H2O2‐induced etching of silver allows real‐time monitoring of H2O2 levels via the second near‐infrared window (NIR‐II) fluorescence (FL) imaging “Turn On”, which delineates tumor boundaries for precise RT and reduce side effects to normal tissue. This dual‐functional platform not only enables real‐time tracking but also enhances therapeutic outcomes, offering a promising approach to precision cancer treatment.https://doi.org/10.1002/advs.202417828bioimagingjanus nanoparticleNIR‐II fluorescence imagingradiotherapyX‐ray |
| spellingShingle | Kang Zhu Zhanyuan Li Jingjing Cao Yixi Cao Jimei Wang Shiyu Wang Ling Chen Huiqin Zhou Wei Huang Hanxun Zou Qunsheng Li Jing Mu Jibin Song Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy Advanced Science bioimaging janus nanoparticle NIR‐II fluorescence imaging radiotherapy X‐ray |
| title | Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy |
| title_full | Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy |
| title_fullStr | Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy |
| title_full_unstemmed | Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy |
| title_short | Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy |
| title_sort | radio activated selenium doped janus ag ag2sexsy nanoparticles for precise cancer nir ii fluorescence imaging and radiosensitization therapy |
| topic | bioimaging janus nanoparticle NIR‐II fluorescence imaging radiotherapy X‐ray |
| url | https://doi.org/10.1002/advs.202417828 |
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