YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders
YAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. Both are known to play a crucial role in defining cellular outcomes, including cell differentiat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1522705/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583809840709632 |
|---|---|
| author | Aderonke O. Ajongbolo Aderonke O. Ajongbolo Sigrid A. Langhans |
| author_facet | Aderonke O. Ajongbolo Aderonke O. Ajongbolo Sigrid A. Langhans |
| author_sort | Aderonke O. Ajongbolo |
| collection | DOAJ |
| description | YAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. Both are known to play a crucial role in defining cellular outcomes, including cell differentiation, cell proliferation, and apoptosis. Aside from the canonical Hippo signaling cascade with the key components MST1/2 (mammalian STE20-like kinase 1/2), SAV1 (Salvador homologue 1), MOB1A/B (Mps one binder kinase activator 1A/B) and LATS1/2 (large tumor suppressor kinase 1/2) upstream of YAP/TAZ, YAP/TAZ activation is also influenced by numerous other signaling pathways. Such non-canonical regulation of YAP/TAZ includes well-known growth factor signaling pathways such as the epidermal growth factor receptor (EGFR)/ErbB family, Notch, and Wnt signaling as well as cell-cell adhesion, cell-matrix interactions and mechanical cues from a cell’s microenvironment. This puts YAP/TAZ at the center of a complex signaling network capable of regulating developmental processes and tissue regeneration. On the other hand, dysregulation of YAP/TAZ signaling has been implicated in numerous diseases including various cancers and neurodevelopmental disorders. Indeed, in recent years, parallels between cancer development and neurodevelopmental disorders have become apparent with YAP/TAZ signaling being one of these pathways. This review discusses the role of YAP/TAZ in brain development, cancer and neurodevelopmental disorders with a special focus on the interconnection in the role of YAP/TAZ in these different conditions. |
| format | Article |
| id | doaj-art-b8326c62d6dc4c8baf721e6a9cb05f02 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-b8326c62d6dc4c8baf721e6a9cb05f022025-01-28T06:41:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011310.3389/fcell.2025.15227051522705YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disordersAderonke O. Ajongbolo0Aderonke O. Ajongbolo1Sigrid A. Langhans2Division of Neurology and Nemours Biomedical Research, Nemours Children’s Health, Wilmington, DE, United StatesBiological Sciences Graduate Program, University of Delaware, Newark, DE, United StatesDivision of Neurology and Nemours Biomedical Research, Nemours Children’s Health, Wilmington, DE, United StatesYAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. Both are known to play a crucial role in defining cellular outcomes, including cell differentiation, cell proliferation, and apoptosis. Aside from the canonical Hippo signaling cascade with the key components MST1/2 (mammalian STE20-like kinase 1/2), SAV1 (Salvador homologue 1), MOB1A/B (Mps one binder kinase activator 1A/B) and LATS1/2 (large tumor suppressor kinase 1/2) upstream of YAP/TAZ, YAP/TAZ activation is also influenced by numerous other signaling pathways. Such non-canonical regulation of YAP/TAZ includes well-known growth factor signaling pathways such as the epidermal growth factor receptor (EGFR)/ErbB family, Notch, and Wnt signaling as well as cell-cell adhesion, cell-matrix interactions and mechanical cues from a cell’s microenvironment. This puts YAP/TAZ at the center of a complex signaling network capable of regulating developmental processes and tissue regeneration. On the other hand, dysregulation of YAP/TAZ signaling has been implicated in numerous diseases including various cancers and neurodevelopmental disorders. Indeed, in recent years, parallels between cancer development and neurodevelopmental disorders have become apparent with YAP/TAZ signaling being one of these pathways. This review discusses the role of YAP/TAZ in brain development, cancer and neurodevelopmental disorders with a special focus on the interconnection in the role of YAP/TAZ in these different conditions.https://www.frontiersin.org/articles/10.3389/fcell.2025.1522705/fullHippobraincancerneurodevelopmental disordermicroenvironmentYAP/TAZ signaling |
| spellingShingle | Aderonke O. Ajongbolo Aderonke O. Ajongbolo Sigrid A. Langhans YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders Frontiers in Cell and Developmental Biology Hippo brain cancer neurodevelopmental disorder microenvironment YAP/TAZ signaling |
| title | YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders |
| title_full | YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders |
| title_fullStr | YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders |
| title_full_unstemmed | YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders |
| title_short | YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders |
| title_sort | yap taz associated cell signaling at the crossroads of cancer and neurodevelopmental disorders |
| topic | Hippo brain cancer neurodevelopmental disorder microenvironment YAP/TAZ signaling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1522705/full |
| work_keys_str_mv | AT aderonkeoajongbolo yaptazassociatedcellsignalingatthecrossroadsofcancerandneurodevelopmentaldisorders AT aderonkeoajongbolo yaptazassociatedcellsignalingatthecrossroadsofcancerandneurodevelopmentaldisorders AT sigridalanghans yaptazassociatedcellsignalingatthecrossroadsofcancerandneurodevelopmentaldisorders |