The Role of the Intraplaque Vitamin D System in Atherogenesis
Vitamin D has been shown to play critical activities in several physiological pathways not involving the calcium/phosphorus homeostasis. The ubiquitous distribution of the vitamin D receptor that is expressed in a variety of human and mouse tissues has strongly supported research on these “nonclassi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2013/620504 |
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| author | Federico Carbone Fabrizio Montecucco |
| author_facet | Federico Carbone Fabrizio Montecucco |
| author_sort | Federico Carbone |
| collection | DOAJ |
| description | Vitamin D has been shown to play critical activities in several physiological pathways not involving the calcium/phosphorus homeostasis. The ubiquitous distribution of the vitamin D receptor that is expressed in a variety of human and mouse tissues has strongly supported research on these “nonclassical” activities of vitamin D. On the other hand, the recent discovery of the expression also for vitamin D-related enzymes (such as 25-hydroxyvitamin D-1α-hydroxylase and the catabolic enzyme 1,25-dihydroxyvitamin D-24-hydroxylase) in several tissues suggested that the vitamin D system is more complex than previously shown and it may act within tissues through autocrine and paracrine pathways. This updated model of vitamin D axis within peripheral tissues has been particularly investigated in atherosclerotic pathophysiology. This review aims at updating the role of the local vitamin D within atherosclerotic plaques, providing an overview of both intracellular mechanisms and cell-to-cell interactions. In addition, clinical findings about the potential causal relationship between vitamin D deficiency and atherogenesis will be analysed and discussed. |
| format | Article |
| id | doaj-art-b830e777002f4744b792fd52b4f158dd |
| institution | DOAJ |
| issn | 2090-908X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-b830e777002f4744b792fd52b4f158dd2025-08-20T03:22:46ZengWileyScientifica2090-908X2013-01-01201310.1155/2013/620504620504The Role of the Intraplaque Vitamin D System in AtherogenesisFederico Carbone0Fabrizio Montecucco1Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 6 Viale Benedetto XV, 16132 Genoa, ItalyDepartment of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, 6 Viale Benedetto XV, 16132 Genoa, ItalyVitamin D has been shown to play critical activities in several physiological pathways not involving the calcium/phosphorus homeostasis. The ubiquitous distribution of the vitamin D receptor that is expressed in a variety of human and mouse tissues has strongly supported research on these “nonclassical” activities of vitamin D. On the other hand, the recent discovery of the expression also for vitamin D-related enzymes (such as 25-hydroxyvitamin D-1α-hydroxylase and the catabolic enzyme 1,25-dihydroxyvitamin D-24-hydroxylase) in several tissues suggested that the vitamin D system is more complex than previously shown and it may act within tissues through autocrine and paracrine pathways. This updated model of vitamin D axis within peripheral tissues has been particularly investigated in atherosclerotic pathophysiology. This review aims at updating the role of the local vitamin D within atherosclerotic plaques, providing an overview of both intracellular mechanisms and cell-to-cell interactions. In addition, clinical findings about the potential causal relationship between vitamin D deficiency and atherogenesis will be analysed and discussed.http://dx.doi.org/10.1155/2013/620504 |
| spellingShingle | Federico Carbone Fabrizio Montecucco The Role of the Intraplaque Vitamin D System in Atherogenesis Scientifica |
| title | The Role of the Intraplaque Vitamin D System in Atherogenesis |
| title_full | The Role of the Intraplaque Vitamin D System in Atherogenesis |
| title_fullStr | The Role of the Intraplaque Vitamin D System in Atherogenesis |
| title_full_unstemmed | The Role of the Intraplaque Vitamin D System in Atherogenesis |
| title_short | The Role of the Intraplaque Vitamin D System in Atherogenesis |
| title_sort | role of the intraplaque vitamin d system in atherogenesis |
| url | http://dx.doi.org/10.1155/2013/620504 |
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