Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients
Background and purpose: Radiotherapy for localized prostate cancer often targets the entire prostate with a uniform dose despite the presence of high-risk dominant intraprostatic lesions (DILs). This study investigated the feasibility of focal dose-averaged linear energy transfer (LETd) boost for pr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Physics and Imaging in Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631625000326 |
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| author | Bo Zhao Nobuyuki Kanematsu Shuri Aoki Shinichiro Mori Hideyuki Mizuno Takamitsu Masuda Hideyuki Takei Hitoshi Ishikawa |
| author_facet | Bo Zhao Nobuyuki Kanematsu Shuri Aoki Shinichiro Mori Hideyuki Mizuno Takamitsu Masuda Hideyuki Takei Hitoshi Ishikawa |
| author_sort | Bo Zhao |
| collection | DOAJ |
| description | Background and purpose: Radiotherapy for localized prostate cancer often targets the entire prostate with a uniform dose despite the presence of high-risk dominant intraprostatic lesions (DILs). This study investigated the feasibility of focal dose-averaged linear energy transfer (LETd) boost for prostate carbon-ion radiotherapy to deposit higher LETd to DILs while ensuring desired relative biological effectiveness weighted dose coverage to targets and sparing organs at risk (OARs). Materials and methods: A retrospective planning study was conducted on 15 localized prostate cancer cases. The DILs were identified on multiparametric MRI and used to define the boost target (PTVboost). Two treatment plans were designed for each patient: 1) conventional plan optimized by the single-field uniform dose technique, and 2) boost plan optimized by the multifield optimization and LET painting technique, to achieve LETd boost within the PTVboost. Dose and LETd metrics of the targets and OARs were compared between the two plans. Results: Compared to the conventional plans, the boost plans delivered clinically acceptable dose coverage (D90% and D50%) to the target (PTV2) within 1% differences while significantly increasing the minimum LETd by 16 ∼ 24 keV/μm for the PTVboost (63.9 ± 2.8 vs. 44.0 ± 1.3 keV/μm, p < 0.001). Furthermore, these improvements were consistent across all cases, irrespective of their anatomical features, including the boost volume’s size, location, and shape. Conclusion: Focal LETd boost was a feasible strategy for prostate carbon-ion radiotherapy. This investigation demonstrated its superiority in delivering LETd boost without depending on tumor location and volume across different cases. |
| format | Article |
| id | doaj-art-b82d37e2117c446f9772745293b5b128 |
| institution | Kabale University |
| issn | 2405-6316 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj-art-b82d37e2117c446f9772745293b5b1282025-02-12T05:31:21ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162025-01-0133100727Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patientsBo Zhao0Nobuyuki Kanematsu1Shuri Aoki2Shinichiro Mori3Hideyuki Mizuno4Takamitsu Masuda5Hideyuki Takei6Hitoshi Ishikawa7Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan; Corresponding authors at: Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan; Corresponding authors at: Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.QST Hospital, National Institutes for Quantum Science and Technology, Chiba, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, JapanQST Hospital, National Institutes for Quantum Science and Technology, Chiba, JapanBackground and purpose: Radiotherapy for localized prostate cancer often targets the entire prostate with a uniform dose despite the presence of high-risk dominant intraprostatic lesions (DILs). This study investigated the feasibility of focal dose-averaged linear energy transfer (LETd) boost for prostate carbon-ion radiotherapy to deposit higher LETd to DILs while ensuring desired relative biological effectiveness weighted dose coverage to targets and sparing organs at risk (OARs). Materials and methods: A retrospective planning study was conducted on 15 localized prostate cancer cases. The DILs were identified on multiparametric MRI and used to define the boost target (PTVboost). Two treatment plans were designed for each patient: 1) conventional plan optimized by the single-field uniform dose technique, and 2) boost plan optimized by the multifield optimization and LET painting technique, to achieve LETd boost within the PTVboost. Dose and LETd metrics of the targets and OARs were compared between the two plans. Results: Compared to the conventional plans, the boost plans delivered clinically acceptable dose coverage (D90% and D50%) to the target (PTV2) within 1% differences while significantly increasing the minimum LETd by 16 ∼ 24 keV/μm for the PTVboost (63.9 ± 2.8 vs. 44.0 ± 1.3 keV/μm, p < 0.001). Furthermore, these improvements were consistent across all cases, irrespective of their anatomical features, including the boost volume’s size, location, and shape. Conclusion: Focal LETd boost was a feasible strategy for prostate carbon-ion radiotherapy. This investigation demonstrated its superiority in delivering LETd boost without depending on tumor location and volume across different cases.http://www.sciencedirect.com/science/article/pii/S2405631625000326Localized prostate cancerCarbon-ion radiotherapyLET paintingDose-averaged LETFocal boost |
| spellingShingle | Bo Zhao Nobuyuki Kanematsu Shuri Aoki Shinichiro Mori Hideyuki Mizuno Takamitsu Masuda Hideyuki Takei Hitoshi Ishikawa Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients Physics and Imaging in Radiation Oncology Localized prostate cancer Carbon-ion radiotherapy LET painting Dose-averaged LET Focal boost |
| title | Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients |
| title_full | Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients |
| title_fullStr | Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients |
| title_full_unstemmed | Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients |
| title_short | Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients |
| title_sort | optimizing the dose averaged linear energy transfer for the dominant intraprostatic lesions in high risk localized prostate cancer patients |
| topic | Localized prostate cancer Carbon-ion radiotherapy LET painting Dose-averaged LET Focal boost |
| url | http://www.sciencedirect.com/science/article/pii/S2405631625000326 |
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