Bioactive Secondary Metabolites from an Arctic Marine-Derived Strain, <i>Streptomyces</i> sp. MNP-1, Using the OSMAC Strategy
An Arctic marine-derived strain, MNP-1, was characterized by a combined methodological approach, incorporating a variety of analytical techniques including morphological features, biochemical characteristics, and 16S ribosomal RNA (rRNA) sequence analysis. The chemical investigation of <i>Stre...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/8/1657 |
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| Summary: | An Arctic marine-derived strain, MNP-1, was characterized by a combined methodological approach, incorporating a variety of analytical techniques including morphological features, biochemical characteristics, and 16S ribosomal RNA (rRNA) sequence analysis. The chemical investigation of <i>Streptomyces</i> sp. MNP-1 using the OSMAC (one strain many compounds) strategy yielded the isolation of twenty known compounds (<b>1–20</b>), which were unambiguously identified by various spectroscopic approaches including <sup>1</sup>H and <sup>13</sup>C NMR and ESI-MS (previously reported data). Bioassay results indicated that compounds <b>2</b>, <b>3</b>, <b>5</b>, <b>9</b>, <b>14</b>, <b>15</b>, and <b>20</b> had antimicrobial activity against human pathogenic strains including <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i> with MIC values ranging from 4 to 32 μg/mL, and compounds <b>3</b> and <b>14</b> exhibited moderate inhibitory activity on A549, MCF-7, and HepG2 tumor lines showing IC<sub>50</sub> values within the range of 19.88 to 35.82 µM. These findings suggest that <i>Streptomyces</i> sp. MNP-1 is one of the prolific manufacturers of bioactive secondary metabolites with therapeutic potential. |
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| ISSN: | 1420-3049 |