Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis
Background. Methicillin-resistant Staphylococcus aureus (MRSA) rates have increased in cystic fibrosis (CF) patients.This study aimed to determine the rate of MRSA, define risk factors, and clarify the effect of MRSA on pulmonary functions, annual pulmonary exacerbation (aPEx) in children wit...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2022-10-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/217 |
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| author | Beste Özsezen Uğur Özçelik Ebru Yalçın Gülşen Hazırolan İsmail Güzelkaş Halime Nayır Büyükşahin Birce Sunman Dilber Ademhan Tural Nagehan Emiralioğlu Deniz Doğru Nural Kiper |
| author_facet | Beste Özsezen Uğur Özçelik Ebru Yalçın Gülşen Hazırolan İsmail Güzelkaş Halime Nayır Büyükşahin Birce Sunman Dilber Ademhan Tural Nagehan Emiralioğlu Deniz Doğru Nural Kiper |
| author_sort | Beste Özsezen |
| collection | DOAJ |
| description |
Background. Methicillin-resistant Staphylococcus aureus (MRSA) rates have increased in cystic fibrosis (CF) patients.This study aimed to determine the rate of MRSA, define risk factors, and clarify the effect of MRSA on pulmonary functions, annual pulmonary exacerbation (aPEx) in children with MRSA positive CF.
Methods. This was a retrospective case control study. CF patients who had ≥1 MRSA (+) respiratory culture between September 2016-2019 were included. MRSA growth rate, colonization status, clinical characteristics, hospitalization rates, FEV1 %predicted, and z-score one year prior to the MRSA isolation, at MRSA growth and one year after MRSA growth were recorded. The aPEx rate changes before-after MRSA growth were evaluated.
Results. Sixty-one subjects who had ≥1MRSA growth and 66 controls were enrolled. There was no statistically significant difference between the spirometry indices at first, and 12th month after MRSA acquisition. The mean aPEx was 0.6 one year prior to MRSA acquisition and this rate significantly increased to 1.2 one year after MRSA growth(p < 0.05). The mean hospitalization rate before and after one year of MRSA acquisition significantly increased from 0.17(±0.12) to 0.48 (±0.3)(p:0.008) admissions per year.
Conclusions. MRSA growth was related to increased aPEx. Increased aPEx and hospitalization rates after MRSA acquisition suggest MRSA should be eradicated when detected.
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| format | Article |
| id | doaj-art-b82ba275524241ef91a0691c7e71089b |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-b82ba275524241ef91a0691c7e71089b2025-08-20T02:55:21ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212022-10-0164510.24953/turkjped.2021.5050Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosisBeste Özsezen0Uğur Özçelik1Ebru Yalçın2Gülşen Hazırolan3İsmail Güzelkaş4Halime Nayır Büyükşahin5Birce Sunman6Dilber Ademhan Tural7Nagehan Emiralioğlu8Deniz Doğru9Nural Kiper10Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Medical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Departments of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Türkiye. Background. Methicillin-resistant Staphylococcus aureus (MRSA) rates have increased in cystic fibrosis (CF) patients.This study aimed to determine the rate of MRSA, define risk factors, and clarify the effect of MRSA on pulmonary functions, annual pulmonary exacerbation (aPEx) in children with MRSA positive CF. Methods. This was a retrospective case control study. CF patients who had ≥1 MRSA (+) respiratory culture between September 2016-2019 were included. MRSA growth rate, colonization status, clinical characteristics, hospitalization rates, FEV1 %predicted, and z-score one year prior to the MRSA isolation, at MRSA growth and one year after MRSA growth were recorded. The aPEx rate changes before-after MRSA growth were evaluated. Results. Sixty-one subjects who had ≥1MRSA growth and 66 controls were enrolled. There was no statistically significant difference between the spirometry indices at first, and 12th month after MRSA acquisition. The mean aPEx was 0.6 one year prior to MRSA acquisition and this rate significantly increased to 1.2 one year after MRSA growth(p < 0.05). The mean hospitalization rate before and after one year of MRSA acquisition significantly increased from 0.17(±0.12) to 0.48 (±0.3)(p:0.008) admissions per year. Conclusions. MRSA growth was related to increased aPEx. Increased aPEx and hospitalization rates after MRSA acquisition suggest MRSA should be eradicated when detected. https://turkjpediatr.org/article/view/217colonizationcystic fibrosismethicillin resistant Staphylococcus aureuspulmonary exacerbationtreatment |
| spellingShingle | Beste Özsezen Uğur Özçelik Ebru Yalçın Gülşen Hazırolan İsmail Güzelkaş Halime Nayır Büyükşahin Birce Sunman Dilber Ademhan Tural Nagehan Emiralioğlu Deniz Doğru Nural Kiper Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis The Turkish Journal of Pediatrics colonization cystic fibrosis methicillin resistant Staphylococcus aureus pulmonary exacerbation treatment |
| title | Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis |
| title_full | Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis |
| title_fullStr | Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis |
| title_full_unstemmed | Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis |
| title_short | Clinical findings of methicillin-resistant Staphylococcus aureus in cystic fibrosis |
| title_sort | clinical findings of methicillin resistant staphylococcus aureus in cystic fibrosis |
| topic | colonization cystic fibrosis methicillin resistant Staphylococcus aureus pulmonary exacerbation treatment |
| url | https://turkjpediatr.org/article/view/217 |
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