Acute Exacerbation of Cold Agglutinin Disease by SARS-CoV-2 Infection: A Rural U.S. Hospital Experience
COVID-19 has been associated with profound hematologic disease processes, including cold agglutinin disease (CAD). We discuss a patient with preexisting stable CAD that was exacerbated by COVID-19. Management of this patient was complicated by the fact that rituximab, a known therapy for CAD, could...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-01-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0133 |
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| Summary: | COVID-19 has been associated with profound hematologic disease processes, including cold agglutinin disease (CAD). We discuss a patient with preexisting stable CAD that was exacerbated by COVID-19. Management of this patient was complicated by the fact that rituximab, a known therapy for CAD, could not be used. Recent reports have shown poorer survival for patients with COVID-19 who received rituximab. In this report, we discuss the pathogenesis of CAD and its management in the context of SARS-CoV-2 infection. We aim to increase awareness of possible exacerbation of CAD by SARS-CoV-2 infection. |
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| ISSN: | 2767-7664 |