Elevated Plasma Angiopoietin-like 4 Protein Levels in Adult Patients with Dengue

Elevated Plasma Angiopoietin-like 4 Protein Levels in Adult Patients with Dengue

Dengue virus infection can cause severe complications due to vascular leakage. Angiopoietin-like protein 4 (ANGPTL4) regulates vascular permeability, but its role in dengue pathogenesis is unclear. This study investigated the association between plasma ANGPTL4 levels and dengue severity in Singapore...

Full description

Saved in:

Bibliographic Details
Main Authors:	Win Khaing, Suk Hiang Lau, Tun-Linn Thein, Nguan Soon Tan, Sylvie Alonso, Shawn Vasoo, Po Ying Chia, David Chien Boon Lye, Yee Sin Leo, Vincent T. K. Chow
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Viruses
Subjects:	dengue angiopoietin-like 4 endothelial dysfunction plasma leakage disease severity healthy controls
Online Access:	https://www.mdpi.com/1999-4915/17/2/226
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically
by: Joanna Kalupa, et al.
Published: (2011-06-01)

Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing
by: Qiong Deng, et al.
Published: (2025-02-01)

Serum angiopoietin-2/angiopoietin-1 ratio is associated with cardiovascular and all-cause mortality in peritoneal dialysis patients: a prospective cohort study
by: Han Li, et al.
Published: (2024-12-01)

Angiopoietins as biomarkers of schistosomiasis severity: a cross-sectional study
by: Rachael Lima Sobreira Coimbra, et al.

Relationship of angiopoietin-2 level with the prognosis of the COVID-19 disease
by: Olgun Keskin, et al.
Published: (2023-10-01)

Arsenic trioxide inhibits angiogenesis of hepatocellular carcinoma after insufficient radiofrequency ablation via blocking paracrine angiopoietin-1 and angiopoietin-2
by: Shuying Dong, et al.
Published: (2022-12-01)

Exploring Angiopoietin-2: Clinical Insights and Experimental Perspectives in Kidney Diseases
by: An-Jie Luo, et al.
Published: (2024-12-01)

The diagnostic and prognostic value of angiopoietins compared with C-reactive protein and procalcitonin in children with febrile neutropenia
by: Esra Mimaroğlu, et al.
Published: (2017-08-01)

Angiopoietin-Like Protein Family-Mediated Functions in Modulating Triglyceride Metabolism and Related Metabolic Diseases
by: Sen Yang, et al.
Published: (2025-03-01)

Angiopoietin-like4 can be used to evaluate and predict efficacy for membranous nephropathy
by: WANG Jian, et al.
Published: (2019-01-01)

Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy
by: Xinling Zhang, et al.
Published: (2025-05-01)

Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease
by: Sy-Harn Lian, et al.
Published: (2022-01-01)

Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target
by: Yan Li, et al.
Published: (2025-01-01)

Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension
by: Heather L. Clark, et al.
Published: (2025-02-01)

Prognostic value of serum angiopoietin-like protein 2 in patients with acute coronary syndrome
by: Guangfeng Zuo, et al.
Published: (2024-12-01)

Angiopoietin‐like 4 is a potential biomarker for diabetic kidney disease in type 2 diabetes patients
by: Yan Wang, et al.
Published: (2024-12-01)

Expression and Predictive Value of Angiopoietin-2 in Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease
by: Ruiqin Ni, et al.
Published: (2025-12-01)

Hormone Receptor‐Dependent Correlations Between Angiopoietins and VEGF‐C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers
by: Vahid Montazeri, et al.
Published: (2025-05-01)

Assessment of World Health Organization definition of dengue hemorrhagic fever in North India
by: Prashant Gupta, et al.
Published: (2010-03-01)

The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model
by: Qiong Deng, et al.
Published: (2024-12-01)

Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis
by: Cheng Tang, et al.
Published: (2020-07-01)

Angiopoietin-like protein 8 promotes apoptosis of vascular smooth muscle cells through activating p53 signaling pathway
by: YU Huahui, DU Zhiyong, JIAO Xiaolu, LYU Qianwen, YANG Yunyun, HAN Lijie, QIN Yanwen
Published: (2025-07-01)

Endothelial GNAQ p.R183Q mutation confers hemoporfin-mediated photodynamic therapy resistance and drives pathological angiogenesis via the angiopoietin-2/TIE2/PI3K/AKT pathway
by: Lu Liu, et al.
Published: (2025-08-01)

Proteomics Analysis of Peripheral Blood Mononuclear Cells from Patients in Early Dengue Infection Reveals Potential Markers of Subsequent Fluid Leakage
by: Nilanka Perera, et al.
Published: (2025-05-01)

Evaluating ovarian function in infertile patients: the combined diagnostic utility of anti-müllerian hormone and angiopoietin-like protein 8
by: Chongbo Du, et al.
Published: (2025-12-01)

Angiopoietin II in Critically Ill Septic Patients: A Post Hoc Analysis of the DRAK Study
by: Veronika Bucher, et al.
Published: (2024-10-01)

The Differences Between Interleukin-6 and C-reactive Protein Levels Among Adult Patients of Dengue Infection with and without Plasma Leakage
by: Eppy Eppy, et al.
Published: (2016-09-01)

The Differences Between Interleukin-6 and C-reactive Protein Levels Among Adult Patients of Dengue Infection with and without Plasma Leakage
by: Eppy Eppy, et al.
Published: (2016-09-01)

Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression
by: Cristina Santos Ferreira, et al.
Published: (2025-03-01)

Antibodies to cyclic citrullinated peptide and angiopoietin-like protein type 4 as markers of immune inflammation and osteoporotic processes in rheumatoid arthritis patients
by: G. Ya. Osmanova, et al.
Published: (2024-01-01)

Ponatinib and other clinically approved inhibitors of Src and Rho-A kinases abrogate dengue virus serotype 2- induced endothelial permeability
by: Srishti Rajkumar Mishra, et al.
Published: (2025-12-01)

Plasma angiopoietin-like protein 4 as a novel biomarker predicting 10-year mortality in a community-based population: a longitudinal cohort study
by: Kang-Chih Fan, et al.
Published: (2024-06-01)

Unfractionated heparin attenuated histone-induced pulmonary endothelial glycocalyx injury through Ang/Tie2 pathway
by: Jia Yin, et al.
Published: (2025-02-01)

Angpt2/Tie2 autostimulatory loop controls tumorigenesis
by: Ninelia Minaskan Karabid, et al.
Published: (2022-03-01)

Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study at a large institution in Singapore
by: Sapna P Sadarangani, et al.
Published: (2024-06-01)

HLA alleles and dengue susceptibility across populations in the era of climate change: a comprehensive review
by: Amit Gourav Ghosh, et al.
Published: (2025-04-01)

Use of metformin in treatment of dengue fever
by: Zainab Irfan, et al.
Published: (2025-01-01)

Factors associated with severe dengue in patients from Cauca, Colombia, 2015–2021
by: Bolaños-Díaz, María Cristina, et al.
Published: (2025-04-01)

Dengue virus serotypes and related factors in children with dengue hemorrhagic fever in Southern Vietnam
by: Khai Quang Tran, et al.
Published: (2024-04-01)

GDM links to increased neonatal myocardial hypertrophy via ANGPTL7: prospective cohort study
by: Weihua Jian, et al.
Published: (2025-12-01)