Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death

Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death

BackgroundAlthough COVID-19 primarily affects the respiratory tract, liver injury has been increasingly reported in infected individuals. The mechanisms by which SARS-CoV-2 induces hepatocyte damage remain poorly understood. Given the role of mitochondrial dysfunction, oxidative stress, and regulate...

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Bibliographic Details
Main Authors: Cintia Cevallos, Patricio Jarmoluk, Franco Sviercz, Rosa Nicole Freiberger, Cynthia Alicia Marcela López, M. Victoria Delpino, Jorge Quarleri
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
hepatocytes
mitochondrial ROS
ferroptosis
lipid metabolism
regulated cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1625928/full
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