Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis
Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation. How...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3891425 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849686197302984704 |
|---|---|
| author | Yingying Wei Linan Peng Yi Li Na Zhang Ke Shang Lihua Duan Jixin Zhong Jie Chen |
| author_facet | Yingying Wei Linan Peng Yi Li Na Zhang Ke Shang Lihua Duan Jixin Zhong Jie Chen |
| author_sort | Yingying Wei |
| collection | DOAJ |
| description | Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation. However, the role of CCN3 in rheumatoid arthritis (RA), a classic autoimmune and inflammatory disease, remains elusive. RA is a chronic systemic autoimmune disease that eventually leads to cartilage and bone destruction and joint dysfunction. In this study, we investigated the potential of serum CCN3 as a biomarker for RA. The serum levels of CCN3 were measured by ELISA. The clinical and laboratory parameters were collected from a clinical record system, and disease activity was determined by joint disease activity score 28 (DAS28). Our results showed that the serum levels of CCN3 were significantly increased in RA patients compared to healthy controls. Furthermore, the CCN3 level was positively correlated with DAS28 (CRP), DAS28 (ESR), and the level of anti-CCP Ab, an autoantibody highly specific for RA. Furthermore, CCN3 showed a positive correlation with inflammatory cytokine IL-6, while no significant correlation with TNF-α was observed. These data suggest that CCN3 plays an important role in the development of RA and might be a potential disease activity biomarker for RA. |
| format | Article |
| id | doaj-art-b82282d9d0184dc88bd9ad49b9981d8a |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b82282d9d0184dc88bd9ad49b9981d8a2025-08-20T03:22:48ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/38914253891425Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid ArthritisYingying Wei0Linan Peng1Yi Li2Na Zhang3Ke Shang4Lihua Duan5Jixin Zhong6Jie Chen7Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Scientific Research and Education, Jiangxi Provincial People’s Hospital, Nanchang University, Nanchang, ChinaNephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation. However, the role of CCN3 in rheumatoid arthritis (RA), a classic autoimmune and inflammatory disease, remains elusive. RA is a chronic systemic autoimmune disease that eventually leads to cartilage and bone destruction and joint dysfunction. In this study, we investigated the potential of serum CCN3 as a biomarker for RA. The serum levels of CCN3 were measured by ELISA. The clinical and laboratory parameters were collected from a clinical record system, and disease activity was determined by joint disease activity score 28 (DAS28). Our results showed that the serum levels of CCN3 were significantly increased in RA patients compared to healthy controls. Furthermore, the CCN3 level was positively correlated with DAS28 (CRP), DAS28 (ESR), and the level of anti-CCP Ab, an autoantibody highly specific for RA. Furthermore, CCN3 showed a positive correlation with inflammatory cytokine IL-6, while no significant correlation with TNF-α was observed. These data suggest that CCN3 plays an important role in the development of RA and might be a potential disease activity biomarker for RA.http://dx.doi.org/10.1155/2020/3891425 |
| spellingShingle | Yingying Wei Linan Peng Yi Li Na Zhang Ke Shang Lihua Duan Jixin Zhong Jie Chen Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis Journal of Immunology Research |
| title | Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis |
| title_full | Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis |
| title_fullStr | Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis |
| title_full_unstemmed | Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis |
| title_short | Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis |
| title_sort | higher serum ccn3 is associated with disease activity and inflammatory markers in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2020/3891425 |
| work_keys_str_mv | AT yingyingwei higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT linanpeng higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT yili higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT nazhang higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT keshang higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT lihuaduan higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT jixinzhong higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis AT jiechen higherserumccn3isassociatedwithdiseaseactivityandinflammatorymarkersinrheumatoidarthritis |