Genetic proxies for clinical traits are associated with increased risk of severe COVID-19

Abstract Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside...

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Bibliographic Details
Main Authors: N. J. M. Chaddock, S. S. R. Crossfield, M. Pujades-Rodriguez, M. M. Iles, A. W. Morgan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-86260-z
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