Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients

Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients

RationaleCOVID-19-associated acute-respiratory distress syndrome (C-ARDS) results from a direct viral injury associated with host excessive innate immune response mainly affecting the lungs. However, cytokine profile in the lung compartment of C-ARDS patients has not been widely studied, nor compare...

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Main Authors: Audrey Cambon, Christophe Guervilly, Clémence Delteil, Nicola Potere, Richard Bachelier, Edwige Tellier, Evelyne Abdili, Marine Leprince, Marco Giani, Ildo Polidoro, Valentina Albanese, Paolo Ferrante, Laurence Coffin, Michael Schiffrin, Laurent Arnaud, Romaric Lacroix, Sandrine Roque, Jean-Marie Forel, Sami Hraiech, Laurent Daniel, Laurent Papazian, Françoise Dignat-George, Gilles Kaplanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
acute respiratory distress syndrome
vasculopathy
caspase-1
cytokines
bronchoalveolar fluid
COVID-19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493306/full
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