MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While the biosynthesis of mycofactocin is well established, the gene mftG, which encodes an oxidoreductase of the glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that Mft...

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Bibliographic Details
Main Authors: Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
Mycolicibacterium smegmatis
Mycofactocin
mycobacteria
respiration
redox-cofactor
oxidoreductase
Online Access:https://elifesciences.org/articles/97559
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https://elifesciences.org/articles/97559

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