CXXC5 function blockade promotes diabetic wound healing through stimulating fibroblast and vascular endothelial cell activation

CXXC5 function blockade promotes diabetic wound healing through stimulating fibroblast and vascular endothelial cell activation

Abstract Background Extracellular matrix (ECM) and angiogenesis are critical controls of wound regeneration, and their dysfunction delays diabetes recovery. CXXC5 belongs to the CXXC protein family that can regulate the function of human dermal fibroblasts (HDFs) and human umbilical vein endothelial...

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Bibliographic Details
Main Authors: Yutong Chen, Xiaofeng Ding, Zhouji Ma, Shuai Shao, Heyan Huang, Yumeng Huang, Beizhi Wang, Hao Zhang, Qian Tan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
CXXC5
Fibroblast
Angiogenesis
Wound healing
Diabetes
Online Access:https://doi.org/10.1186/s12964-025-02097-z
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