Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia
Objectives Acute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context. Methods This prospective observational, single-cen...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241276482 |
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| author | Sebnem Calik Oktay Bilgir İsmail Demir Selma Tosun Yeliz Özdemir |
| author_facet | Sebnem Calik Oktay Bilgir İsmail Demir Selma Tosun Yeliz Özdemir |
| author_sort | Sebnem Calik |
| collection | DOAJ |
| description | Objectives Acute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context. Methods This prospective observational, single-center study included 114 patients diagnosed with acute leukemia. Tregs percentages were measured using flow cytometry. Statistical analyses involved logistic regression to identify factors significantly associated with survival. Results Of the 114 patients, 78 recovered, while 36 died. The median Treg percentages were 5.9% in patients under 65 years and 5.38% in those 65 and older. A lower percentage of Tregs was associated with higher mortality in the older group (p = 0.04). Multivariate analysis highlighted the presence of comorbidities, documented infections, and day seven C-reactive protein levels as significant predictors of survival. Conclusion This study supports the importance of monitoring chronic diseases and infection foci alongside traditional markers like C-reactive protein. Future research should explore the mechanistic roles of Tregs in immunosuppression and survival in this vulnerable population. |
| format | Article |
| id | doaj-art-b804af076afe410e804602b23bb0f968 |
| institution | DOAJ |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-b804af076afe410e804602b23bb0f9682025-08-20T02:52:46ZengSAGE PublishingJournal of International Medical Research1473-23002025-03-015310.1177/03000605241276482Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropeniaSebnem CalikOktay Bilgirİsmail DemirSelma TosunYeliz ÖzdemirObjectives Acute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context. Methods This prospective observational, single-center study included 114 patients diagnosed with acute leukemia. Tregs percentages were measured using flow cytometry. Statistical analyses involved logistic regression to identify factors significantly associated with survival. Results Of the 114 patients, 78 recovered, while 36 died. The median Treg percentages were 5.9% in patients under 65 years and 5.38% in those 65 and older. A lower percentage of Tregs was associated with higher mortality in the older group (p = 0.04). Multivariate analysis highlighted the presence of comorbidities, documented infections, and day seven C-reactive protein levels as significant predictors of survival. Conclusion This study supports the importance of monitoring chronic diseases and infection foci alongside traditional markers like C-reactive protein. Future research should explore the mechanistic roles of Tregs in immunosuppression and survival in this vulnerable population.https://doi.org/10.1177/03000605241276482 |
| spellingShingle | Sebnem Calik Oktay Bilgir İsmail Demir Selma Tosun Yeliz Özdemir Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia Journal of International Medical Research |
| title | Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| title_full | Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| title_fullStr | Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| title_full_unstemmed | Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| title_short | Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| title_sort | evaluation of the effects of regulatory t cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia |
| url | https://doi.org/10.1177/03000605241276482 |
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